MYCN oncogene and angiogenesis: down-regulation of endothelial growth inhibitors in human neuroblastoma cells. Purification, structural, and functional characterization

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dc.contributor.authorHatzi, E.en
dc.contributor.authorBreit, S.en
dc.contributor.authorZoephel, A.en
dc.contributor.authorAshman, K.en
dc.contributor.authorTontsch, U.en
dc.contributor.authorAhorn, H.en
dc.contributor.authorMurphy, C.en
dc.contributor.authorSchweigerer, L.en
dc.contributor.authorFotsis, T.en
dc.date.accessioned2015-11-24T19:02:49Z
dc.date.available2015-11-24T19:02:49Z
dc.identifier.issn0065-2598-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19840
dc.rightsDefault Licence-
dc.subjectActivinsen
dc.subjectAmino Acid Sequenceen
dc.subject*Angiogenesis Inhibitorsen
dc.subjectCell Divisionen
dc.subjectCells, Cultureden
dc.subject*Down-Regulationen
dc.subjectEndothelium, Vascular/cytologyen
dc.subject*Gene Expression Regulation, Neoplasticen
dc.subjectGlycoproteins/*geneticsen
dc.subjectHumansen
dc.subjectInhibins/*geneticsen
dc.subjectMolecular Sequence Dataen
dc.subjectMolecular Weighten
dc.subjectNeovascularization, Pathologic/*metabolismen
dc.subjectNeuroblastomaen
dc.subjectOncogenesen
dc.subjectProto-Oncogene Proteins c-myc/*geneticsen
dc.subjectTumor Cells, Cultureden
dc.titleMYCN oncogene and angiogenesis: down-regulation of endothelial growth inhibitors in human neuroblastoma cells. Purification, structural, and functional characterizationen
heal.abstractAngiogenesis, the formation of new blood vessels, is seen during embryonic development and tumor progression, but the mechanisms have remained unclear. Recent data indicate that tumor angiogenesis can be induced by cellular oncogenes, leading to the enhanced activity of molecules stimulating angiogenesis. However, activated oncogenes might also facilitate angiogenesis by down-regulating endogenous inhibitors of angiogenesis. We report here that enhanced expression of the N-myc oncogene in human neuroblastoma cells down-regulates three inhibitors of endothelial cell proliferation. One of them was identified by amino acid sequencing as being identical with activin A, a developmentally-regulated protein. Down-regulation involves interaction of the N-myc protein with the activin A promoter. Work is ongoing to characterize the other two endothelial cell inhibitors. We suggest that the N-myc induced down-regulation of angiogenesis inhibitors could contribute to tumor angiogenesis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10949669-
heal.journalNameAdv Exp Med Biolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2000-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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