Structural, photolysis and biological studies of the bis(mu(2)-chloro)-tris(triphenylphosphine)-di-copper(I) and chloro-tris(triphenylphosphine)- copper(I) complexes. Study of copper(I)-copper(I) interactions
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Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Inorganica Chimica Acta
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Direct reaction of copper(I) chloride with triphenylphosphine (tpp) in molar ratio 2: 3 and 1: 3, results in the formation of the [(tpp)Cu(mu(2)-Cl)(2)Cu(tpp)(2)] (1) and {[CuCl(tpp)(3)]center dot(CH3CN)} (2) complexes. The complexes have been characterized by melting point, FT-IR, UV-Vis spectroscopic data and X-ray crystallography. Complex 1 is di-nuclear. Two mu(2)-Cl atoms bridge two copper(I) ions with tetrahedral and trigonal geometry respectively. The short copper-copper bond distance of 2.9039(6) angstrom in case of 1 indicates d(10)-d(10) interaction between metal centers. Thus, our studies were extended here in the determination of the quasi-aromaticity, which results in strong Cu-Cu interactions, using the computational method of nucleus-independent chemical shifts (NICS). The NICS calculated at the inner region of the Cu2Cl2P3 core in complex 1 is shielded up to -6.05 ppm. Complex 2 is mono-nuclear where three phosphorus and one chloride atoms form a tetrahedron around the copper(I) ion. Photolysis of both complexes 1 and 2, results in the formation of triphenylphosphine oxide. The complexes 1 and 2, were tested for their in vitro cytotoxic activity against leiomyosarcoma cells (LMS) and human breast adenocarcinoma cells (MCF-7). The type of LMS cell death caused by the complexes was also evaluated by use of a flow cytometry assay. The results show that at concentration of 5 mu M of complexes 1 and 2, 34.1% (1) and 19.6 (2)% of LMS cells undergo programmed cell death (apoptosis), while at 10 mu M, 80.4% (1) and 65.2% (2) of LMS cells undergo apoptosis. The light sensitivity of the complex is discussed in relation with the biological activity. (C) 2009 Elsevier B. V. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
Bioinorganic chemistry, Copper(I) complexes, Triphenylphosphine, Crystal, structures, Photolysis, Biological studies, Cytotoxic activity, coinage metal-clusters, d-orbital aromaticity, crystal-structure, heterocyclic thiones, molecular structure, ligand, triphenylphosphine, hydrocarbons, mononuclear, phosphine
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://WOS:000274414700018
http://ac.els-cdn.com/S0020169309006859/1-s2.0-S0020169309006859-main.pdf?_tid=a2289b86-cce4-11e2-80cd-00000aacb35d&acdnat=1370329492_a7cb809f6d748f9834c64739f50d29e6
http://ac.els-cdn.com/S0020169309006859/1-s2.0-S0020169309006859-main.pdf?_tid=a2289b86-cce4-11e2-80cd-00000aacb35d&acdnat=1370329492_a7cb809f6d748f9834c64739f50d29e6
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής