Short-term hormone therapy improves sCD40L and endothelial function in early menopausal women: Potential role of estrogen receptor polymorphisms

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dc.contributor.authorBechlioulis, A.en
dc.contributor.authorNaka, K. K.en
dc.contributor.authorKalantaridou, S. N.en
dc.contributor.authorChatzikyriakidou, A.en
dc.contributor.authorPapanikolaou, O.en
dc.contributor.authorKaponis, A.en
dc.contributor.authorVakalis, K.en
dc.contributor.authorVezyraki, P.en
dc.contributor.authorGartzonika, K.en
dc.contributor.authorMavridis, A.en
dc.contributor.authorGeorgiou, I.en
dc.contributor.authorMichalis, L. K.en
dc.date.accessioned2015-11-24T18:51:42Z
dc.date.available2015-11-24T18:51:42Z
dc.identifier.issn1873-4111-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18296
dc.rightsDefault Licence-
dc.titleShort-term hormone therapy improves sCD40L and endothelial function in early menopausal women: Potential role of estrogen receptor polymorphismsen
heal.abstractOBJECTIVE: Hormone therapy (HT) has been suggested to improve vascular function and inflammation in menopausal women, although not consistently. We aimed to investigate the effects of HT on endothelial function and inflammation, especially sCD40L, in early menopausal women, and the effect of common estrogen receptor (ER) polymorphisms on vascular responses to HT. STUDY DESIGN: Eighty-four early menopausal women (<3 years in menopause) with menopausal complaints eligible for HT. Forty women received transdermal 17beta-estradiol plus cyclical micronized progesterone for 3 months while 44 did not (controls). MAIN OUTCOME MEASURES: Brachial artery flow-mediated dilation (FMD) and vascular inflammation markers (sICAM, sP-Selectin and sCD40L). Genetic polymorphisms of ERalpha (PvuII 454-397T>C and XbaI 454-351A>G) and ERbeta (AluI 1730A>G) were also assessed. RESULTS: The two groups did not differ at baseline. Following HT, vasomotor complaints' severity, blood pressure, LDL, sCD40L, sICAM and sP-Selectin decreased and FMD increased compared to controls (P<0.05 for all). ERbeta AluI A allele presence was the most important independent predictor of HT-induced increase in FMD while ERalpha XbaI A allele was the only independent predictor of decrease in sCD40L. CONCLUSIONS: Short-term HT in early menopausal women improved endothelial function and inflammation. Specific ER polymorphisms that were found to be main determinants of HT-induced effects on endothelium could identify subgroups of women who may benefit the most from HT.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.maturitas.2012.01.001-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/22277987-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0378512212000114/1-s2.0-S0378512212000114-main.pdf?_tid=cdcf46c8e7fc800bff1171ad460f3f22&acdnat=1333463308_78338ca91f31c8b036d022d3e36051ff-
heal.journalNameMaturitasen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2012-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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