Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription
| dc.contributor.author | Karetsou, Z. | en |
| dc.contributor.author | Kretsovali, A. | en |
| dc.contributor.author | Murphy, C. | en |
| dc.contributor.author | Tsolas, O. | en |
| dc.contributor.author | Papamarcaki, T. | en |
| dc.date.accessioned | 2015-11-24T18:55:50Z | |
| dc.date.available | 2015-11-24T18:55:50Z | |
| dc.identifier.issn | 1469-221X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18939 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | CREB-Binding Protein | en |
| dc.subject | Cattle | en |
| dc.subject | Glutathione Transferase/metabolism | en |
| dc.subject | HeLa Cells | en |
| dc.subject | Humans | en |
| dc.subject | NF-kappa B/metabolism | en |
| dc.subject | Nuclear Proteins/*metabolism | en |
| dc.subject | Precipitin Tests | en |
| dc.subject | Protein Precursors/*metabolism | en |
| dc.subject | Rats | en |
| dc.subject | Thymosin/*analogs & derivatives/*metabolism | en |
| dc.subject | Trans-Activators/*metabolism | en |
| dc.subject | Transcription Factor AP-1/metabolism | en |
| dc.subject | Transcription, Genetic/*physiology | en |
| dc.title | Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription | en |
| heal.abstract | Prothymosin alpha (ProTalpha) is a histone H1-binding protein localized in sites of active transcription in the nucleus. We report here that ProTalpha physically interacts with the CREB-binding protein (CBP), which is a versatile transcription co-activator. Confocal laser scanning microscopy reveals that ProTalpha partially colocalizes with CBP in discrete subnuclear domains. Using transient transfections, we show that ProTalpha synergizes with CBP and stimulates AP1- and NF-kappaB-dependent transcription. Furthermore, overexpression of ProTalpha enhances the transactivation potential of CBP. These findings reveal a new function for ProTalpha in transcription activation, probably through CBP-mediated recruitment to different promoters. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1093/embo-reports/kvf071 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11897665 | - |
| heal.identifier.secondary | http://www.nature.com/embor/journal/v3/n4/pdf/embor187.pdf | - |
| heal.journalName | EMBO Rep | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2002 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: