Vitamin D receptor gene polymorphisms and risk of prostate cancer: a meta-analysis
| dc.contributor.author | Ntais, C. | en |
| dc.contributor.author | Polycarpou, A. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T19:41:20Z | |
| dc.date.available | 2015-11-24T19:41:20Z | |
| dc.identifier.issn | 1055-9965 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24472 | |
| dc.rights | Default Licence | - |
| dc.subject | Age Distribution | en |
| dc.subject | Aged | en |
| dc.subject | Case-Control Studies | en |
| dc.subject | Confidence Intervals | en |
| dc.subject | Gene Expression Regulation, Neoplastic | en |
| dc.subject | Genetic Markers/genetics | en |
| dc.subject | *Genetic Predisposition to Disease | en |
| dc.subject | Humans | en |
| dc.subject | Incidence | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Odds Ratio | en |
| dc.subject | *Polymorphism, Genetic | en |
| dc.subject | Prognosis | en |
| dc.subject | Prostatic Neoplasms/*epidemiology/*genetics | en |
| dc.subject | Receptors, Calcitriol/*genetics | en |
| dc.subject | Reference Values | en |
| dc.subject | Risk Factors | en |
| dc.subject | Sensitivity and Specificity | en |
| dc.title | Vitamin D receptor gene polymorphisms and risk of prostate cancer: a meta-analysis | en |
| heal.abstract | Several polymorphisms in the vitamin D receptor (VDR) gene have been implicated as risk factors for prostate cancer. We performed a meta-analysis of 14 studies (17 comparisons) with TaqI genotyping (1870 prostate cancer cases; 2843 controls), 6 studies (8 comparisons) with poly(A) repeat genotyping (540 cases; 870 controls), 5 studies with BsmI genotyping (987 cases; 1504 controls), and 3 studies with FokI genotyping (514 cases; 545 controls). The random-effects odds ratio (OR) for the t versus T allele was 0.95 [95% confidence interval (CI), 0.86-1.05]. There was no suggestion of an overall effect either in recessive or dominant modeling, and the comparison of t/t versus T/T also showed no differential prostate cancer susceptibility (OR, 0.88; 95% CI, 0.70-1.10). No effect of t was seen in subjects of European descent (nine comparisons; OR, 0.97; 95% CI, 0.87-1.08), Asian descent (five comparisons; OR, 0.88; 95% CI, 0.66-1.17), or African descent (three comparisons; OR, 0.94; 95% CI, 0.41-2.17). There was no between-study heterogeneity in any of these analyses. Overall, the random effects OR was 0.94 (95% CI, 0.75-1.18; no between-study heterogeneity) for the S versus L allele, 0.92 (95% CI, 0.63-1.35; P < 0.01 for heterogeneity) for the B versus b allele, and 1.03 (95% CI, 0.86-1.23; no between-study heterogeneity) for the f versus F allele. The meta-analysis shows that these four polymorphisms are unlikely to be major determinants of susceptibility to prostate cancer on a wide population basis. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/14693728 | - |
| heal.identifier.secondary | http://cebp.aacrjournals.org/content/12/12/1395.full.pdf | - |
| heal.journalName | Cancer Epidemiol Biomarkers Prev | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2003 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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