Stress through handling for vaginal screening, serotonin, and ACTH response to ether
| dc.contributor.author | Sfikakis, A. | en |
| dc.contributor.author | Galanopoulou, P. | en |
| dc.contributor.author | Konstandi, M. | en |
| dc.contributor.author | Tsakayannis, D. | en |
| dc.date.accessioned | 2015-11-24T18:50:27Z | |
| dc.date.available | 2015-11-24T18:50:27Z | |
| dc.identifier.issn | 0091-3057 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18076 | |
| dc.rights | Default Licence | - |
| dc.subject | Adrenal Glands/anatomy & histology/physiology | en |
| dc.subject | Adrenocorticotropic Hormone/*blood | en |
| dc.subject | Anesthetics, Inhalation/*toxicity | en |
| dc.subject | Animals | en |
| dc.subject | Diestrus/physiology | en |
| dc.subject | Ether, Ethyl/*toxicity | en |
| dc.subject | Female | en |
| dc.subject | *Handling (Psychology) | en |
| dc.subject | Hypothalamus/metabolism/physiology | en |
| dc.subject | Organ Size/physiology | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Serotonin/*metabolism | en |
| dc.subject | Stress, Psychological/metabolism/*physiopathology | en |
| dc.subject | Thymus Gland/anatomy & histology/physiology | en |
| dc.subject | Vagina/*physiology | en |
| dc.subject | Weight Gain/physiology | en |
| dc.title | Stress through handling for vaginal screening, serotonin, and ACTH response to ether | en |
| heal.abstract | The effect of duration of handling for vaginal smear screening on the adrenal weight and acute ACTH response to ether were examined in 4-day-cycling female rats, sacrificed at 97-103 days of age on diestrus-2 after evaluation of resistance to handling, thymus weight, and hypothalamic serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA). Prolonged handling paralleled increased resistance (behavioral response) to handling and adrenal weight but was inversely related to thymus weight. The hypothalamic 5-HT, 5-HIAA, and 5-HIAA/5-HT ratio, compared to controls with similar conditions of handling, were not modified after 2.5 min of ether despite the ACTH rise. In ether-stressed rats, the ACTH response to ether was lower after prolonged handling compared to short handling paralleling decreased thymus weight. In contrast, 5-HT, 5-HIAA, and the 5-HIAA/5-HT ratio were higher, paralleling increased resistance and adrenal weight. The results suggest chronic activation of the hypothalamo-pituitary-adrenal axis with positive serotonergic involvement after prolonged handling and resistance during vaginal screening and a negative implication of this activation on the acute ACTH response to ether. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8801604 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/0091305795020896/1-s2.0-0091305795020896-main.pdf?_tid=c1634e708669aa0c802b761d652fff20&acdnat=1332760095_04c3e0aab243fada64160e4e571a203c | - |
| heal.journalName | Pharmacol Biochem Behav | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1996 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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