Effect of biological response modifiers on growth and cell proliferation of human tumor xenografts in nude mice

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dc.contributor.authorMaurer-Schultze, B.en
dc.contributor.authorBassukas, I. D.en
dc.contributor.authorHofmockel, G.en
dc.date.accessioned2015-11-24T19:23:03Z
dc.date.available2015-11-24T19:23:03Z
dc.identifier.issn0145-5680-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22234
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectCachexia/etiology/prevention & controlen
dc.subjectCarcinoma, Renal Cell/complications/drug therapy/pathology/*therapyen
dc.subjectCarcinoma, Squamous Cell/complications/drug therapy/pathology/*therapyen
dc.subjectCell Division/drug effectsen
dc.subjectCombined Modality Therapyen
dc.subjectDrug Interactionsen
dc.subjectDrug Screening Assays, Antitumoren
dc.subjectEtoposide/pharmacology/therapeutic useen
dc.subjectFemaleen
dc.subjectGranulocyte-Macrophage Colony-Stimulating Factor/pharmacology/*therapeutic useen
dc.subjectHumansen
dc.subjectHypopharyngeal Neoplasmsen
dc.subjectImmunologic Factors/pharmacology/*therapeutic useen
dc.subjectInterferon-alpha/pharmacology/*therapeutic useen
dc.subjectKidney Neoplasmsen
dc.subjectMiceen
dc.subjectMice, Nudeen
dc.subjectNeoplasm Transplantationen
dc.subjectNeoplastic Stem Cells/drug effectsen
dc.subjectRecombinant Proteins/pharmacology/therapeutic useen
dc.subjectTransplantation, Heterologousen
dc.subjectTumor Necrosis Factor-alpha/pharmacology/*therapeutic useen
dc.titleEffect of biological response modifiers on growth and cell proliferation of human tumor xenografts in nude miceen
heal.abstractThe effect of biological response modifiers on macroscopic tumor growth and on tumor cell proliferation of a human renal cell carcinoma and a squamous cell carcinoma (hypopharynx) in nude mice has been studied. Tumor necrosis factor alpha (TNF-alpha) and interferon alpha (IFN-alpha) as well as granulocyte-macrophage colony-stimulating factor (GM-CSF) were applied either alone or in combination, and TNF-alpha was also combined with etoposide (ETP). TNF-alpha and IFN-alpha alone or in combination did not substantially affect the course of tumor growth, however, they did influence the pattern of tumor growth. There was also only a marginal effect on tumor cell proliferation. However, IFN-alpha protects the animals from tumor growth associated weight loss. ETP and ETP plus TNF-alpha leads to a deceleration of tumor growth, a decrease of the labeling index and to a significant decrease of the animal weight which indicates that the first two effects may be partly due to the toxicity of the treatment. GM-CSF modifies cell proliferation in a dose-dependent manner, i.e. stimulation at low doses and tendency to inhibition at higher doses. Although there is no substantial direct antineoplastic effect of the agents studied, the results make clear that indirect effects of therapeutic agents due to therapy induced cachexia should always be regarded. It is interesting that IFN-alpha has a protective effect against cachexia.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7773138-
heal.journalNameCell Mol Biol (Noisy-le-grand)en
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1995-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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