Statin-Induced Increase in HDL-C and Renal Function in Coronary Heart Disease Patients
| dc.contributor.author | Athyros, V. G. | en |
| dc.contributor.author | Kakafika, A. I. | en |
| dc.contributor.author | Papageorgiou, A. A. | en |
| dc.contributor.author | Pagourelias, E. D. | en |
| dc.contributor.author | Savvatianos, S. D. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.contributor.author | Karagiannis, A. | en |
| dc.contributor.author | Tziomalos, K. | en |
| dc.contributor.author | Mikhailidis, D. P. | en |
| dc.date.accessioned | 2015-11-24T18:50:39Z | |
| dc.date.available | 2015-11-24T18:50:39Z | |
| dc.identifier.issn | 1874-1924 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18120 | |
| dc.rights | Default Licence | - |
| dc.title | Statin-Induced Increase in HDL-C and Renal Function in Coronary Heart Disease Patients | en |
| heal.abstract | BACKGROUND: Little is known about the potential of statin-induced high-density lipoprotein cholesterol (HDL-C) increase to improve renal function in coronary heart disease (CHD) patients. METHODS AND RESULTS: In thispost hocanalysis of the GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) Study we investigated the effect of HDL-C increase after statin treatment on renal function. From a total of 1,600 patients, 880 were on various statins (mainly atorvastatin) and 720 were not. Other secondary prevention therapies were similar in the 2 groups. After a 3 year follow up, the lipid profile was unchanged in the statin untreated group and estimated glomerular filtration rate (eGFR) was reduced by 5.1% compared with baseline (P<0.0001). In contrast, in the statin treated group non-HDL-C was reduced by 43%, HDL-C was increased by 7% and there was a significant increase in eGFR compared with baseline by 9.8% (P<0.0001). In multiple regression analysis, the mean 7% increase in HDL-C in the treated arm during the entire study was associated with a 5.6% increase in eGFR recorded after the 6(th) week of treatment. The odds ratio of eGFR increase with every 5% statin-induced rise in HDL-C was 1.78 (95% confidence interval 1.19-3.34; P=0.001). CONCLUSIONS: Statin treatment significantly improved renal function. Statin-induced HDL-C increase significantly and independently contributed to this improvement. This finding supports the concept that improving lipid variables other than low density lipoprotein cholesterol is also beneficial to preserving renal function. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.2174/1874192400701010008 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/18949085 | - |
| heal.journalName | Open Cardiovasc Med J | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2007 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |