Synthesis, structural characterization and in vitro cytotoxic activity of the bis-(2,6-di-tert-butylphenol)tin(IV) dichloride and its complexes with heterocyclic thioamides

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dc.contributor.authorShpakovsky, D. B.en
dc.contributor.authorBanti, C. N.en
dc.contributor.authorBeaulieu-Houle, G.en
dc.contributor.authorKourkoumelis, N.en
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorManoli, M.en
dc.contributor.authorManos, M. J.en
dc.contributor.authorTasiopoulos, A. J.en
dc.contributor.authorMilaeva, E. R.en
dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorBakas, T.en
dc.contributor.authorButler, I. S.en
dc.contributor.authorHadjiliadi, N.en
dc.date.accessioned2015-11-24T16:49:42Z
dc.date.available2015-11-24T16:49:42Z
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9523
dc.rightsDefault Licence-
dc.titleSynthesis, structural characterization and in vitro cytotoxic activity of the bis-(2,6-di-tert-butylphenol)tin(IV) dichloride and its complexes with heterocyclic thioamidesen
heal.abstractFour new organotin(IV) complexes of bis-(2,6-di-tert-butylphenol)tin(IV) dichloride [(tert-Bu-)2(HO-Ph)]2SnCl2 (1) with the heterocyclic thioamides 2-mercapto-pyrimidine (PMTH), 2-mercapto-4-methyl-pyrimidine (MPMTH), 2-mercapto-pyridine (PYTH) and 2-mercapto-benzothiazole (MBZTH), of formulae {[(tert-Bu-)2(HO-Ph)]2Sn(PMT)2} (2), {[(tert-Bu-)2(HO-Ph)]2Sn(MPMT)2} (3), {[(tert-Bu-)2(HO-Ph)]2SnCl(PYT)} (4) and {[(tert-Bu-)2(HO-Ph)]2SnCl(MBZT)} (5), have been synthesized and characterized by elemental analysis, 1H-, 13C-, 119Sn-NMR, EPR, FT-IR, Raman and Mössbauer spectroscopic techniques. The crystal and molecular structures of compounds 1-5 have been determined by X-ray diffraction. The geometries around the metal center adopted in complexes 1-5 varied between tetrahedral in 1, trigonal bipyramidal in 3, 4, 5 and distorted octahedral in 2. Two carbon atoms from aryl groups and two chlorine atoms form a distorted tetrahedron in the case of 1. Two carbon, two sulfur and two nitrogen atoms from thione ligands form a distorted octahedral geometry around tin(IV) with trans-C2, cis-N2, cis-S2-configurations in 2. However, in the case of 4 and 5 complexes two carbon, one sulfur, one nitrogen and one chloride atom form a distorted trigonal bipyramidal arrangement. Finally, in the case of 3 the trigonal bipyramidal geometry is achieved by two carbon, two sulfur and one nitrogen atom in a unique coordination mode of thioamides toward the tin(IV) cation. Compounds 1-5 were tested for their in vitro cytotoxicity against the human breast adenocarcinoma (MCF-7) cell line. Compound 3 exhibits strong cytotoxic activity against MCF-7 cells (IC50 = 0.58 ± 0.1 μM).en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1039/C2DT31527K-
heal.identifier.secondaryhttp://pubs.rsc.org/en/Content/ArticleLanding/2012/DT/c2dt31527k#!divAbstract-
heal.journalNameDalton Transactionsen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2012-
heal.publisherRoyal Society of Chemistryen
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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