Synthesis, structural characterization and in vitro cytotoxicity of organotin(IV) derivatives of heterocyclic thioamides, 2-mercaptobenzothiazole, 5-chloro-2-mercaptobenzothiazole, 3-methyl-2-mercaptobenzothiazole and 2-mercaptonicotinic acid
Φόρτωση...
Ημερομηνία
Συγγραφείς
Xanthopoulou, M. N.
Hadjikakou, S. K.
Hadjiliadis, N.
Schurmann, M.
Jurkschat, K.
Michaelides, A.
Skoulika, S.
Bakas, T.
Binolis, J.
Karkabounas, S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Elsevier
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Inorg Biochem
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Five new organotin(IV) molecules with the heterocyclic thioamides; 2-inereaptobenzothiazole (Hmbzt), 5-chloro-2-mercaptobenzothiazole (Hcmbzt), 3-methyl-2-mercaptobenzothiazole (mmbzt) and 2-mercaptonicotinic acid (H(2)mna) of formulae [(n-C4H9)(2)Sn(mbzt)(2)] (1), [(C6H5)(2)Sn(mbzt)(2)] (2), {(CH3)(2)Sn(cmbzt)(2)].1.7(H2O)} (3), [(n-C4H9)(2)SnCl2(mmbzt)(2).(CH2Cl2)] (4) and {[(C6H5)(3)Sn](2)(nma).[(CH3)(2)CO]} (5) have been synthesized and characterized by elemental analysis, H-1-, C-13-NMR, FT-IR and Mossbauer spectroscopic techniques. Crystal structures of molecules 1, 3 and 5 have been determined by X-ray diffraction at 173(l) K (I and 5) and 293(2) K (3). Compound 1 C22H26N2S4Sn, is monoclinic, space group C2/c, a =44.018(2), b = 8.8864(5), c = 12.8633(7) Angstrom, beta = 104.195(5)degrees, Z = 8. Compound 3 is also monoclinic, space group P2(1)/c and a = 17.128(2) Angstrom, b = 17.919(2) Angstrom, c = 7.3580(10) Angstrom, beta = 98.290(10)degrees, Z=4. In both molecules 1 and 3, two carbon atoms from aryl groups, two sulfur and two nitrogen atoms from thione ligands form a distorted octahedral geometry around tin(IV) with trans-C-2, cis-N-2, cis-S-2 configurations. Compound 5 C45H39NO3SSn2 is monoclinic, space group P2(1)/n, a=9.1148(2) Angstrom, b=29.2819(6), c=15.5556(4) Angstrom, beta=106.285](9)degrees, Z=4. Complex 5 contains two I(C6H5)3Sn(IV)] moieties linked by a double deprotonated 2-mercaptonicotinic acid (H(2)mna). Both tin(IV) ions are five coordinated. This complex is the an example of a pentacoordinated Ph3SnXY system with an axial-equatorial arrangement of the phenyl groups at Sn(1) atom. Compounds 1, 3 and 5 were tested for in vitro cytotoxicity against the cancer cell line of sarcoma cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (benzo[a]pyrene) carcinogenesis. Compound 5 exhibits strong cytotoxic activity, while complexes 1 and 3 show less cytotoxic activity. (C) 2003 Elsevier Inc. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
bioinorganic chemistry, organotin(iv) molecules, s ligands-heterocyclic thioamides, crystal structures, molecular-structure, crystal-structure, mossbauer-spectroscopy, trypanocidal activity, complexes, ligands, 6-thiopurine
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000184654800017
http://ac.els-cdn.com/S0162013403001788/1-s2.0-S0162013403001788-main.pdf?_tid=17617768ec38a4aac9969596d4fec454&acdnat=1333030323_92bb6b2c5f1813dc25d1a2637b3c189e
http://ac.els-cdn.com/S0162013403001788/1-s2.0-S0162013403001788-main.pdf?_tid=17617768ec38a4aac9969596d4fec454&acdnat=1333030323_92bb6b2c5f1813dc25d1a2637b3c189e
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας