ADAM12-s in coelomic fluid and maternal serum in early pregnancy
| dc.contributor.author | Makrydimas, G. | en |
| dc.contributor.author | Sotiriadis, A. | en |
| dc.contributor.author | Spencer, K. | en |
| dc.contributor.author | Cowans, N. J. | en |
| dc.contributor.author | Nicolaides, K. H. | en |
| dc.date.accessioned | 2015-11-24T19:37:42Z | |
| dc.date.available | 2015-11-24T19:37:42Z | |
| dc.identifier.issn | 0197-3851 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24069 | |
| dc.rights | Default Licence | - |
| dc.subject | ADAM Proteins/*blood | en |
| dc.subject | Adult | en |
| dc.subject | Amniotic Fluid/chemistry/*metabolism | en |
| dc.subject | Body Fluids/chemistry/*metabolism | en |
| dc.subject | Female | en |
| dc.subject | Fetus | en |
| dc.subject | Gestational Age | en |
| dc.subject | Humans | en |
| dc.subject | Membrane Proteins/*blood | en |
| dc.subject | Pregnancy/*blood | en |
| dc.subject | Prenatal Diagnosis/*methods | en |
| dc.subject | Reference Values | en |
| dc.subject | Trophoblasts/*metabolism | en |
| dc.title | ADAM12-s in coelomic fluid and maternal serum in early pregnancy | en |
| heal.abstract | OBJECTIVES: ADAM12-s is a placental protein. In early pregnancy, reduced maternal levels of ADAM12-s have been reported in association with foetal trisomy 21 or 18 and in cases that subsequently develop pre-eclampsia and foetal growth restriction. The aim of this study is to investigate the distribution of ADAM12-s in early pregnancy by comparing its concentration in maternal serum, amniotic fluid and coelomic fluid. METHODS: Coelomic fluid was obtained by coelocentesis from 13 singleton pregnancies with live foetuses at 6.9-9.3 weeks of gestation. Maternal serum was also obtained in all cases and in six cases amniotic fluid was also obtained. The concentration of ADAM12-s was measured by dissociation enhanced lanthanide fluoro-immunoassay. RESULTS: The median concentration of ADAM12-s in maternal serum was 132.7 (range 33.8-254.5) ng/mL and in coelomic fluid it was 10.5 (range 1.3-15.8) ng/mL; there were no detectable levels in five of the six amniotic fluid samples. The concentration of maternal serum ADAM12-s increased significantly with gestation (r = 0.862, p < 0.0001). There was no significant association between coelomic fluid ADAM12-s and either gestation (r = 0.255, p = 0.401) or maternal serum ADAM12-s (r = 0.302, p = 0.316). CONCLUSION: The distribution of ADAM12-s in maternal serum and the early embryonic fluid compartments is consistent with its syncytiotrophoblastic origin. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1002/pd.1581 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17139693 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/pd.1581/asset/1581_ftp.pdf?v=1&t=h0l48pht&s=4452c1490b3a6467856e6acfdddeb838f75e3117 | - |
| heal.journalName | Prenat Diagn | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2006 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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