C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors

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dc.contributor.authorIoannidis, P.en
dc.contributor.authorTrangas, T.en
dc.contributor.authorDimitriadis, E.en
dc.contributor.authorSamiotaki, M.en
dc.contributor.authorKyriazoglou, I.en
dc.contributor.authorTsiapalis, C. M.en
dc.contributor.authorKittas, C.en
dc.contributor.authorAgnantis, N.en
dc.contributor.authorNielsen, F. C.en
dc.contributor.authorNielsen, J.en
dc.contributor.authorChristiansen, J.en
dc.contributor.authorPandis, N.en
dc.date.accessioned2015-11-24T16:32:34Z
dc.date.available2015-11-24T16:32:34Z
dc.identifier.issn0020-7136-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7565
dc.rightsDefault Licence-
dc.subjectAmino Acid Motifsen
dc.subjectAnimalsen
dc.subjectBase Sequenceen
dc.subjectCell Divisionen
dc.subjectChromosome Mappingen
dc.subjectDNA, Complementary/metabolismen
dc.subjectHumansen
dc.subjectMesenchymoma/*metabolismen
dc.subjectMiceen
dc.subjectMolecular Sequence Dataen
dc.subjectProtein Bindingen
dc.subjectProto-Oncogene Proteins c-myc/metabolismen
dc.subjectRNA/metabolismen
dc.subjectRNA,en
dc.titleC-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumorsen
heal.abstractMouse coding region determinant-binding (mCRD-BP) and human IGF-II mRNA-binding 1 (hIMP-1) proteins are orthologous mRNA-binding proteins that recognize c-myc and IGF-II mRNA, respectively, and regulate their expression posttranscriptionally. Here, we confirm that human CRD-BP/IMP-1 binds to c-myc mRNA and that it is predominantly expressed in fetal tissues. Moreover, hCRD-BP/IMP-1 expression was detected in cell lines of neoplastic origin and in selected primary tumors. In a series of 33 malignant and 10 benign mesenchymal tumors, 73% and 40%, respectively, were found to express hCRD-BP/IMP-1. In particular, expression was significant in 14 Ewing's sarcomas, all of which were positive. The data suggest that hCRD-BP/IMP-1 plays a role in abnormal cell proliferation in mesenchymal tumors.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11745432-
heal.journalNameInt J Canceren
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2001-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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