Cpp, an Nmda-Receptor Antagonist, Blocks 4-Aminopyridine-Induced Spreading Depression Episodes but Not Epileptiform Activity in Immature Rat Hippocampal Slices
| dc.contributor.author | Psarropoulou, C. | en |
| dc.contributor.author | Avoli, M. | en |
| dc.date.accessioned | 2015-11-24T16:34:50Z | |
| dc.date.available | 2015-11-24T16:34:50Z | |
| dc.identifier.issn | 0304-3940 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7861 | |
| dc.rights | Default Licence | - |
| dc.subject | immature hippocampus | en |
| dc.subject | 4-aminopyridine | en |
| dc.subject | spreading depression | en |
| dc.subject | non-nmda receptor antagonist | en |
| dc.subject | nmda receptor antagonist | en |
| dc.title | Cpp, an Nmda-Receptor Antagonist, Blocks 4-Aminopyridine-Induced Spreading Depression Episodes but Not Epileptiform Activity in Immature Rat Hippocampal Slices | en |
| heal.abstract | Spontaneous episodes of spreading depression (SD) were observed in the CA3 subfield of immature or young (2-30 days postnatally) hippocampal slices perfused with medium containing 4-aminopyridine (4-AP, 50-mu-M). SD appeared in 34% of the hippocampal slices examined and was more frequently observed in slices obtained from 11 to 20-day-old animals. SD studied with extracellular field potential recordings consisted of large amplitude (18.7 +/- 1.1 mV, mean +/- S.E.M.) negative DC shifts that lasted 30-250 s. Unlike the epileptiform activity that was concomitantly seen during 4-AP application, SD was blocked by the NMDA receptor antagonist 3-((RS)-2-carboxypiperazine-4-yl)-propyl-l-phosphonic acid (CPP, 2-10-mu-M). In contrast, 6-cyano-7-nitro-quinoxaline-2,3-dione (CNQX, 5-mu-M), a non-NMDA-type receptor antagonist, blocked the epileptiform activity but only increased the interval between SD episodes. These results demonstrate that immature hippocampal tissue is susceptible to SD episodes, when perfused with 4-AP-containing medium, and that the occurrence of these episodes presumably depends on the activation of the NMDA receptor. In addition these findings indicate that SD shows a sensitivity to excitatory amino acid receptor antagonists that differs from that of the epileptiform activity recorded simultaneously. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://A1992HC66200034 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/030439409290155Z/1-s2.0-030439409290155Z-main.pdf?_tid=9aa5798e-ad80-11e2-bdaa-00000aacb362&acdnat=1366878043_b244d56edd801a5499e8a9c7556d3210 | - |
| heal.journalName | Neurosci Lett | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1992 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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