Synthesis and in vitro cytotoxicity of lipophilic platinum(II) complexes
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Date
Authors
Kokotos, G.
Theodorou, V.
Constantinou-Kokotou, V.
Gibbons, W. A.
Roussakis, C.
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Elsevier
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peer reviewed
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Bioorganic and Medicinal Chemistry Letters
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Description
A number of lipophilic platinum(II) complexes of the general structures cis-[Pt(LA)(2)Cl-2] and [Pt(LD)Cl-2] were synthesised. Long chain amines (LA) and diamines (LD), prepared from lipidic amino acids, were used as ligands. The in vitro cytotoxicity of the complexes was evaluated against four cell lines (P388, NSCLC-N6, E39, M96). cis-Dichloro-bis(2-aminohexadecanol)platinum(II) was the most active against P388, NSCLC-N6 and E39 (IC50: 11 mu g/ml, 25 mu g/ml, 31 mu g/ml), while dichloro(1,3-heptadecanediamine)platinum presented the highest activity against M96 (IC50: 13 mu g/ml). (C) 1998 Elsevier Science Ltd. All rights reserved.
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Keywords
lipidic amino-acids, protein-kinase-c, cyto-toxicity, cis-dichlorodiammineplatinum(ii), peptides, analogs, invitro, agents, growth, cells
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<Go to ISI>://000074291800017
http://ac.els-cdn.com/S0960894X9800256X/1-s2.0-S0960894X9800256X-main.pdf?_tid=8795a208-3640-11e3-981b-00000aab0f02&acdnat=1381913833_3f9f57069fa93c24ea10aa796c768cb7
http://ac.els-cdn.com/S0960894X9800256X/1-s2.0-S0960894X9800256X-main.pdf?_tid=8795a208-3640-11e3-981b-00000aab0f02&acdnat=1381913833_3f9f57069fa93c24ea10aa796c768cb7
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας