Neurodevelopmental outcome of fetuses with increased nuchal translucency and apparently normal prenatal and/or postnatal assessment: a systematic review

Απλή σελίδα τεκμηρίου
dc.contributor.authorSotiriadis, A.en
dc.contributor.authorPapatheodorou, S.en
dc.contributor.authorMakrydimas, G.en
dc.date.accessioned2015-11-24T19:02:18Z
dc.date.available2015-11-24T19:02:18Z
dc.identifier.issn1469-0705-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19786
dc.rightsDefault Licence-
dc.subjectChild, Preschoolen
dc.subjectDevelopmental Disabilities/*epidemiology/etiology/physiopathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectMaleen
dc.subject*Nuchal Translucency Measurementen
dc.subjectPregnancyen
dc.subjectPregnancy Outcomeen
dc.subjectPregnancy Trimester, Firsten
dc.subjectPrognosisen
dc.subjectPsychomotor Performanceen
dc.subjectRisk Factorsen
dc.titleNeurodevelopmental outcome of fetuses with increased nuchal translucency and apparently normal prenatal and/or postnatal assessment: a systematic reviewen
heal.abstractOBJECTIVES: To systematically review and, when feasible, pool, published data regarding the prevalence of childhood neurodevelopmental delay in fetuses with increased first-trimester nuchal translucency (NT), normal karyotype and absence of structural defects or identifiable syndromes. METHODS: MEDLINE and SCOPUS searches using combinations of the terms 'nuchal translucency' AND 'outcome*' were complemented by perusal of the references of the retrieved articles and an additional automated search using the 'search for related articles' PubMed function. Only children with a normal karyotype and no structural defects or syndromic abnormalities were included in the analysis. Between-studies heterogeneity was assessed using the I(2) statistic. RESULTS: The total prevalence of developmental delay in all 17 studies was 28/2458 (1.14%; 95% CI, 0.79-1.64; I(2) = 57.6%). Eight studies (n = 1567) used NT > 99(th) centile as the cut-off; 15 children (0.96%; 95% CI, 0.58-1.58%) were reported as having developmental delay (I(2) = 72.2%). Four studies (n = 669) used the 95(th) centile as the cut-off for increased NT; seven children (1.05%; 95% CI, 0.51-4.88%) were reported as having developmental delay (I(2) = 29.2%). Five studies used 3.0 mm as the cut-off for increased NT; the pooled rate of developmental delay was six of 222 children (2.70%; 95% CI, 1.24-5.77%; I(2) = 0.0%). CONCLUSION: The rate of neurodevelopmental delay in children with increased fetal NT, a normal karyotype, normal anatomy and no identifiable genetic syndromes does not appear to be higher than that reported for the general population. More large-scale, prospective case-control studies would be needed to enhance the robustness of the results.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1002/uog.10143-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/22102486-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/uog.10143/asset/10143_ftp.pdf?v=1&t=h0l473vx&s=5ed8a501657dcc7a092f44a2ba6abba2348d07ba-
heal.journalNameUltrasound Obstet Gynecolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2012-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ