Skewed X-chromosome inactivation in Greek women with idiopathic recurrent miscarriage

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dc.contributor.authorDasoula, A.en
dc.contributor.authorKalantaridou, S.en
dc.contributor.authorSotiriadis, A.en
dc.contributor.authorPavlou, M.en
dc.contributor.authorGeorgiou, I.en
dc.contributor.authorParaskevaidis, E.en
dc.contributor.authorMakrigiannakis, A.en
dc.contributor.authorSyrrou, M.en
dc.date.accessioned2015-11-24T18:51:18Z
dc.date.available2015-11-24T18:51:18Z
dc.identifier.issn1421-9964-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18239
dc.rightsDefault Licence-
dc.subjectAbortion, Habitual/*geneticsen
dc.subjectAdulten
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHeterozygoteen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectOdds Ratioen
dc.subjectPolymerase Chain Reactionen
dc.subjectPregnancyen
dc.subjectProspective Studiesen
dc.subjectReceptors, Androgen/geneticsen
dc.subject*X Chromosome Inactivationen
dc.titleSkewed X-chromosome inactivation in Greek women with idiopathic recurrent miscarriageen
heal.abstractOBJECTIVES: To investigate if skewed X-chromosome inactivation (XCI) is associated with unexplained recurrent miscarriage (RM) in Greek women. METHODS: This was a prospective case-control study. A methylation-sensitive assay was used to investigate the X-inactivation pattern of women with unexplained RM and controls. RESULTS: Fifty-six of the 74 patients (75.7%) and 55 of 80 controls (68.8%) were informative. Among the informative cases, 6/56 (10.7%) women showed extreme XCI (>90%) and among the informative controls, 2/55 (3.6%) showed extreme XCI. CONCLUSIONS: In the present study, women with unexplained RM showed a statistically nonsignificant increase in skewed XCI prevalence (10.7%) compared with control women (3.6%; p = 0.271).en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1159/000116741-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18417978-
heal.identifier.secondaryhttp://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000116741-
heal.journalNameFetal Diagn Theren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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