Antineoplastic and cytogenetic effects of platinum(II) and palladium(II) complexes with pyridine-2-carboxyaldehyde-thiosemicarbazone

Απλή σελίδα τεκμηρίου
dc.contributor.authorKovala-Demertzi, D.en
dc.contributor.authorDemertzis, M. A.en
dc.contributor.authorVaragi, V.en
dc.contributor.authorPapageorgiou, A.en
dc.contributor.authorMourelatos, D.en
dc.contributor.authorMioglou, E.en
dc.contributor.authorIakovidou, Z.en
dc.contributor.authorKotsis, A.en
dc.date.accessioned2015-11-24T16:51:40Z
dc.date.available2015-11-24T16:51:40Z
dc.identifier.issn0009-3157-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9766
dc.rightsDefault Licence-
dc.subjectsister chromatid exchangesen
dc.subjectcell kineticsen
dc.subjectplatinum(ii) and palladium(ii) complexesen
dc.subjectpyridine-2-carboxyaldehyde thiosemicarbazoneen
dc.subjectantileukemic activityen
dc.subjectchromatid exchange assayen
dc.subjectvivo antitumor-activityen
dc.subjectspectral propertiesen
dc.subjectin-vitroen
dc.subject2-acetylpyridineen
dc.subjectthiosemicarbazonesen
dc.subjectpredictionen
dc.subjectantifungalen
dc.subjectinvivoen
dc.titleAntineoplastic and cytogenetic effects of platinum(II) and palladium(II) complexes with pyridine-2-carboxyaldehyde-thiosemicarbazoneen
heal.abstractThe effect of six novel complexes of Pt(II) and Pd(II) with pyridine-2-carboxyaldehyde thiosemicarbazone (HPyTsc) on sister chromatid exchange rate and human lymphocyte proliferation kinetic was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing cytogenetic and antineoplastic effects are the complexes [Pd(PyTsc)(2)] and [Pt(PyTsc)(2)]. Next in order of magnitude in inducing antineoplastic and cytogenetic effects is the compound [Pt(HPyTsc)(2)]Cl-2 while the rest, i.e. [Pd(PyTsc)Cl], HPyTsc, [Pd(HPyTsc)(2)]Cl-2, and [Pt(PyTsc)Cl], show marginal cytogenetic and antineoplastic effects.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000076569400009-
heal.identifier.secondaryhttp://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000007154-
heal.journalNameChemotherapyen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate1998-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ