Reinnervation after end-to-side nerve coaptation in a rat model
| dc.contributor.author | Zhang, Z. | en |
| dc.contributor.author | Soucacos, P. N. | en |
| dc.contributor.author | Bo, J. | en |
| dc.contributor.author | Beris, A. E. | en |
| dc.contributor.author | Malizos, K. N. | en |
| dc.contributor.author | Ioachim, E. | en |
| dc.contributor.author | Agnantis, N. J. | en |
| dc.date.accessioned | 2015-11-24T18:54:36Z | |
| dc.date.available | 2015-11-24T18:54:36Z | |
| dc.identifier.issn | 1078-4519 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18706 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Axons/ultrastructure | en |
| dc.subject | Disease Models, Animal | en |
| dc.subject | Myelin Sheath | en |
| dc.subject | *Nerve Regeneration | en |
| dc.subject | Neural Conduction | en |
| dc.subject | Neurosurgical Procedures | en |
| dc.subject | Peroneal Nerve/anatomy & histology/physiology/*surgery | en |
| dc.subject | Random Allocation | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Sprague-Dawley | en |
| dc.subject | Tibial Nerve/anatomy & histology/physiology/*surgery | en |
| dc.title | Reinnervation after end-to-side nerve coaptation in a rat model | en |
| heal.abstract | We assessed the effectiveness of end-to-side nerve coaptation by evaluating the extent of reinnervation and the integrity of the donor nerve in the rat. Fifty-six Sprague-Dawley rats were randomly divided into "fresh" and "predegenerated" (delayed) repair groups with or without a window in the perineurium. The right peroneal nerve was cut and sutured to the tibial nerve in an end-to-side fashion. Two and 3 months postoperatively, we measured the nerve conduction velocity (NCV) of the peroneal and tibial nerves, took dry muscle weights, and performed histologic studies. Peroneal NCV recovered up to 71% (2 mo) and 79% (3 mo), and tibial NCV recovered up to 88% (2 mo) and 91% (3 mo). The latter results indicate that this procedure had a slightly negative effect on donor tibial NCV. Dry weight of the tibialis anterior muscle returned to 60% (2 mo) and 82% (3 mo) of that of the contralateral side. Histologic results showed that there were numerous regenerating axons in the distal end of the peroneal nerve. Presence of a window in the perineurium improved the histologic profile significantly. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11370947 | - |
| heal.journalName | Am J Orthop (Belle Mead NJ) | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2001 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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