Magnetization transfer ratio in the brain of preterm subjects: age-related changes during the first 2 years of life
| dc.contributor.author | Xydis, V. | en |
| dc.contributor.author | Astrakas, L. | en |
| dc.contributor.author | Zikou, A. | en |
| dc.contributor.author | Pantou, K. | en |
| dc.contributor.author | Andronikou, S. | en |
| dc.contributor.author | Argyropoulou, M. I. | en |
| dc.date.accessioned | 2015-11-24T19:05:47Z | |
| dc.date.available | 2015-11-24T19:05:47Z | |
| dc.identifier.issn | 0938-7994 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20242 | |
| dc.rights | Default Licence | - |
| dc.subject | Age Factors | en |
| dc.subject | Brain/*anatomy & histology/pathology | en |
| dc.subject | Child, Preschool | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Imaging, Three-Dimensional/methods | en |
| dc.subject | Infant | en |
| dc.subject | Magnetic Resonance Imaging/*methods | en |
| dc.subject | Male | en |
| dc.subject | Nerve Fibers, Myelinated/physiology | en |
| dc.subject | Pregnancy | en |
| dc.subject | *Premature Birth | en |
| dc.title | Magnetization transfer ratio in the brain of preterm subjects: age-related changes during the first 2 years of life | en |
| heal.abstract | To study the progress of myelination in preterm-born subjects by measuring the MT ratio (MTR) from birth, up to 24 months of corrected age. One hundred twenty-five preterm subjects (64 males and 61 females of gestational age 33+/-2.4 weeks with chronologic and corrected age of 9.3+/-5.1 and 7.7+/-5.1 months, respectively) with normal brain MR using classic sequences were further evaluated for MTR by using a three-dimensional gradient-echo sequence (TR=32/TE=8/flip angle=6 degrees 4 mm/2 mm overlapping sections) with and without magnetization transfer prepulse. The magnetization transfer ratio was calculated as: MTR=(SIo-SIm)/SIox100%, where SIm refers to signal intensity from an image acquired with a MT prepulse and SIo the signal intensity from the image acquired without a MT prepulse. MTR increased asymptotically in the genu (R2=0.85) and splenium (R2=0.85) of the corpus callosum, the white matter of the frontal lobe (R2=0.91) and occipital lobe (R2=0.82), thalamus (R2=0.86), caudate nucleus (R2=0.67) and putamen (R2=0.71), reaching the 95% of the final value at the corrected age 18.7, 17.7, 15.6, 12.9, 10.4, 9.2 and 6.4 months, respectively. This study shows age-related changes of the brain MTR and provides data that may be useful to assess disturbances in the progress of myelination. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1007/s00330-005-2796-8 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15965662 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/w4888v6778x00507/fulltext.pdf | - |
| heal.journalName | European Radiology | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2006 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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