Dose-dependent effect of rosuvastatin treatment on urinary protein excretion

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dc.contributor.authorKostapanos, M. S.en
dc.contributor.authorMilionis, H. J.en
dc.contributor.authorSaougos, V. G.en
dc.contributor.authorLagos, K. G.en
dc.contributor.authorKostara, C.en
dc.contributor.authorBairaktari, E. T.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T19:23:39Z
dc.date.available2015-11-24T19:23:39Z
dc.identifier.issn1074-2484-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22351
dc.rightsDefault Licence-
dc.subjectAlpha-Globulins/urineen
dc.subjectDose-Response Relationship, Drugen
dc.subjectFemaleen
dc.subjectFluorobenzenes/administration & dosage/adverse effects/*pharmacologyen
dc.subjectGlomerular Filtration Rate/drug effectsen
dc.subjectHumansen
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage/adverseen
dc.subjecteffects/*pharmacologyen
dc.subjectHyperlipidemias/drug therapy/physiopathologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectProspective Studiesen
dc.subjectProteinuria/chemically induced/*diagnosisen
dc.subjectPyrimidines/administration & dosage/adverse effects/*pharmacologyen
dc.subjectSulfonamides/administration & dosage/adverse effects/*pharmacologyen
dc.titleDose-dependent effect of rosuvastatin treatment on urinary protein excretionen
heal.abstractConcerns have been raised because of observations of proteinuria associated with rosuvastatin treatment. In this open-label study, a potential dose-dependent effect was investigated of rosuvastatin on urinary protein excretion and renal function parameters in 90 hyperlipidemic patients randomly assigned to rosuvastatin 10 mg/day (n = 45) or 20 mg/day (n = 45). Urinary samples were collected from patients and 40 age- and gender-matched controls to determine electrolyte, uric acid, creatinine, and protein (total, albumin, IgG, and alpha1-microglobulin) levels at baseline and after 12 weeks. A dose-dependent increase in the excretion of alpha1-microglobulin (17.6% in rosuvastatin 10 vs 34.9% in rosuvastatin, 20 mg/day; P = .03 for the comparison between groups) was observed. A trend toward an increase in the estimated glomerular filtration rate was noted in only patients receiving 20 mg/day of rosuvastatin. These findings indicate that rosuvastatin treatment increases the urinary excretion of alpha1-microglobulin urinary excretion in a dose-dependent manner without adversely affecting renal function.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1177/1074248407306676-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18172223-
heal.identifier.secondaryhttp://cpt.sagepub.com/content/12/4/292.full.pdf-
heal.journalNameJ Cardiovasc Pharmacol Theren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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