Diffusion and conformation of peptide-functionalized polyphenylene dendrimers studied by fluorescence correlation and C-13 NMR spectroscopy

Απλή σελίδα τεκμηρίου
dc.contributor.authorKoynov, K.en
dc.contributor.authorMihov, G.en
dc.contributor.authorMondeshki, M.en
dc.contributor.authorMoon, C.en
dc.contributor.authorSpiess, H. W.en
dc.contributor.authorMullen, K.en
dc.contributor.authorButt, H. J.en
dc.contributor.authorFloudas, G.en
dc.date.accessioned2015-11-24T18:30:19Z
dc.date.available2015-11-24T18:30:19Z
dc.identifier.issn1525-7797-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/16357
dc.rightsDefault Licence-
dc.subjectsolid-state nmren
dc.subjectdynamicsen
dc.subjectdiagnosticsen
dc.subjectstabilityen
dc.subjectpolymersen
dc.titleDiffusion and conformation of peptide-functionalized polyphenylene dendrimers studied by fluorescence correlation and C-13 NMR spectroscopyen
heal.abstractWe report on the combined use of fluorescence correlation spectroscopy (FCS) and H-1 and C-13 NMR spectroscopy to detect the size and type of peptide secondary structures in a series of poly-Z-L-lysine functionalized polyphenylene dendrimers bearing the fluorescent perylenediimide core in solution. In dilute solution, the size of the molecule as detected from FCS and H-1 NMR diffusion measurements matches nicely. We show that FCS is a sensitive probe of the core size as well as of the change in the peptide secondary structure. However, FCS is less sensitive to functionality. A change in the peptide secondary conformation from beta-sheets to alpha-helices detected by C-13 NMR spectroscopy gives rise to a steep increase in the hydrodynamic radii for number of residues n >= 16. Nevertheless, helices are objects of low persistence.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1021/Bm0702760-
heal.identifier.secondary<Go to ISI>://000246413600047-
heal.identifier.secondaryhttp://pubs.acs.org/doi/abs/10.1021/bm0702760-
heal.journalNameBiomacromoleculesen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)