Premature Atherosclerosis in Non-Transfusion-Dependent beta-Thalassemia Intermedia
| dc.contributor.author | Hahalis, G. | en |
| dc.contributor.author | Kalogeropoulos, A. | en |
| dc.contributor.author | Terzis, G. | en |
| dc.contributor.author | Tselepis, A. D. | en |
| dc.contributor.author | Kourakli, A. | en |
| dc.contributor.author | Mylona, P. | en |
| dc.contributor.author | Grapsas, N. | en |
| dc.contributor.author | Alexopoulos, D. | en |
| dc.date.accessioned | 2015-11-24T16:45:20Z | |
| dc.date.available | 2015-11-24T16:45:20Z | |
| dc.identifier.issn | 0008-6312 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8914 | |
| dc.rights | Default Licence | - |
| dc.subject | beta-thalassemia intermedia | en |
| dc.subject | atherosclerosis | en |
| dc.subject | coronary artery | en |
| dc.subject | venous thromboembolism | en |
| dc.subject | cardiovascular events | en |
| dc.subject | risk | en |
| dc.title | Premature Atherosclerosis in Non-Transfusion-Dependent beta-Thalassemia Intermedia | en |
| heal.abstract | Objectives: beta-Thalassemias are inherited hemolytic anemias with a broad phenotype and an increased rate of vascular complications despite a near absence of coronary artery disease. Methods: We investigated the presence of endothelial dysfunction and subclinical atherosclerosis in non-transfusion-dependent patients with beta-thalassemia intermedia (beta-TI) by means of flow-mediated (FMD) and flow-independent (FID) brachial artery dilatation and carotid artery intima-media thickness. Results: In 20 nondiabetic young adults with beta-TI, FMD (6.6 +/- 3.7 vs. 10.3 +/- 3.1%; p = 0.002) and FID (14.0 +/- 4.7 vs. 18.0 +/- 5.6%; p = 0.02) were both lower relative to the values in 20 matched control subjects, whereas the intima-media thickness was increased (0.51 +/- 0.09 vs. 0.46 +/- 0.07 mm; p = 0.049). Fibrin generation, soluble endothelial activation markers, and proinflammatory proteins were higher in the patient group, while the plasma cholesterol level was lower. Conclusions: These findings indicate premature atherosclerosis among patients with beta-TI; this is in accord with the high incidence of noncoronary vascular episodes in beta-TI. Copyright (C) 2011 S. Karger AG, Basel | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | Doi 10.1159/000327997 | - |
| heal.identifier.secondary | <Go to ISI>://000292037300003 | - |
| heal.identifier.secondary | http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000327997 | - |
| heal.journalName | Cardiology | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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