B-cell differentiation immunophenotypes in classical Hodgkin lymphomas

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dc.contributor.authorBai, M.en
dc.contributor.authorPanoulas, V.en
dc.contributor.authorPapoudou-Bai, A.en
dc.contributor.authorHorianopoulos, N.en
dc.contributor.authorKitsoulis, P.en
dc.contributor.authorStefanaki, K.en
dc.contributor.authorRontogianni, D.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:33:25Z
dc.date.available2015-11-24T19:33:25Z
dc.identifier.issn1042-8194-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23535
dc.rightsDefault Licence-
dc.subjectAntigens, Differentiation/biosynthesisen
dc.subjectB-Lymphocytes/*immunology/pathologyen
dc.subjectCell Differentiation/*immunologyen
dc.subjectGerminal Center/pathologyen
dc.subjectHodgkin Disease/*immunology/pathologyen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectImmunophenotypingen
dc.subjectInterferon Regulatory Factors/biosynthesisen
dc.subjectMembrane Glycoproteins/biosynthesisen
dc.subjectNeprilysin/biosynthesisen
dc.subjectPhenotypeen
dc.subjectProteoglycans/biosynthesisen
dc.subjectProto-Oncogene Proteins c-bcl-6/biosynthesisen
dc.subjectSyndecan-1en
dc.subjectSyndecansen
dc.titleB-cell differentiation immunophenotypes in classical Hodgkin lymphomasen
heal.abstractThe bcl6/CD10/MUM1/CD138 B-cell differentiation immunophenotypes were analysed in 101 cases of classical Hodgkin lymphomas (cHL) aiming to elucidate their histogenesis. Three major bcl6/CD10/MUM1/CD138 immunophenotypes were distinguished on the basis of the immunohistochemical positivity of Hodgkin and Reed-Sternberg (H/RS) cells: (a) the late germinal center (GC)/early post-GC B-cell-like immunophenotype (bcl6-/CD10-/MUM1+/CD138-); 59/101 cases (59%), (b) the post-GC B-cell-like immunophenotype (bcl6-/CD10-/MUM1+/CD138+); 24/101 cases (24%) and (c) the indeterminate immunophenotype (bcl6+/CD10-/MUM1+/CD138-: 14 cases and bcl6+/CD10-/MUM1+/CD138+: four cases); 18/101 cases (18%). The above findings indicate that H/RS cells in most cHL display bcl6/CD10/MUM1/CD138 immunophenotypes consistent with late GC/early post-GC or post-GC B-cell differentiation. In addition, H/RS cells in a small fraction of cHL display indeterminate bcl6/CD10/MUM1/CD138 immunophenotypic profiles which are characterized by simultaneous expression of GC, late GC/early post-GC and post-GC B-cell differentiation proteins. These immunophenotypic profiles do not correspond to the differentiation immunophenotypes of normal B-cells and their identification in a part of cHL suggests that the differentiation process of H/RS cells is not complete in a fraction of these cells and/or is still ongoing at the time of observation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1080/10428190500306784-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16396774-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.1080/10428190500306784-
heal.journalNameLeuk Lymphomaen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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