Molecular defects causing ovarian dysfunction
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Date
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Kalantaridou, S. N.
Chrousos, G. P.
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peer-reviewed
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Ann N Y Acad Sci
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The functions of the hypothalamic-pituitary-ovarian and -adrenal axes are intertwined, and molecular defects in either axis may cause ovarian dysfunction. Advances in molecular genetics have allowed new insights into the pathophysiology of ovarian disorders. Specific gene mutations causing delayed puberty and/or ovarian failure, and heterosexual or isosexual precocious puberty have recently been described. The molecular insights gained into ovarian dysfunction have already led to rational therapies for some of these conditions.
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Keywords
Aromatase/metabolism, Female, Humans, Hypogonadism/genetics/metabolism, Luteinizing Hormone/genetics/physiology, Male, Mutation, Ovarian Diseases/*genetics, Primary Ovarian Insufficiency/genetics, Puberty, Delayed/genetics, Puberty, Precocious/genetics
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http://www.ncbi.nlm.nih.gov/pubmed/10818390
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής