Maternal smoking during pregnancy and childhood lymphoma: a meta-analysis

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dc.contributor.authorAntonopoulos, C. N.en
dc.contributor.authorSergentanis, T. N.en
dc.contributor.authorPapadopoulou, C.en
dc.contributor.authorAndrie, E.en
dc.contributor.authorDessypris, N.en
dc.contributor.authorPanagopoulou, P.en
dc.contributor.authorPolychronopoulou, S.en
dc.contributor.authorPourtsidis, A.en
dc.contributor.authorAthanasiadou-Piperopoulou, F.en
dc.contributor.authorKalmanti, M.en
dc.contributor.authorSidi, V.en
dc.contributor.authorMoschovi, M.en
dc.contributor.authorPetridou, E. T.en
dc.date.accessioned2015-11-24T19:05:17Z
dc.date.available2015-11-24T19:05:17Z
dc.identifier.issn1097-0215-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20170
dc.rightsDefault Licence-
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectHodgkin Disease/*etiologyen
dc.subjectHumansen
dc.subjectLymphoma, Non-Hodgkin/*etiologyen
dc.subjectMothersen
dc.subjectPregnancyen
dc.subjectPregnancy Complications, Neoplastic/*etiologyen
dc.subjectPrognosisen
dc.subjectRisk Factorsen
dc.subjectSmoking/*adverse effectsen
dc.subjectSurvival Rateen
dc.titleMaternal smoking during pregnancy and childhood lymphoma: a meta-analysisen
heal.abstractResults from epidemiological studies exploring the association between childhood lymphoma and maternal smoking during pregnancy have been contradictory. This meta-analysis included all published cohort (n = 2) and case-control (n = 10) articles; among the latter, the data of the Greek Nationwide Registry for Childhood Hematological Malignancies study were updated to include all recently available cases (-2008). Odds ratios (ORs), relative risks and hazard ratios were appropriately pooled in three separate analyses concerning non-Hodgkin lymphoma (NHL, n = 1,072 cases), Hodgkin lymphoma (HL, n = 538 cases) and any lymphoma (n = 1,591 cases), according to data availability in the included studies. An additional metaregression analysis was conducted to explore dose-response relationships. A statistically significant association between maternal smoking (any vs. no) during pregnancy and risk for childhood NHL was observed (OR = 1.22, 95% confidence interval, CI: 1.03-1.45, fixed effects model), whereas the risk for childhood HL was not statistically significant (OR = 0.90, 95% CI: 0.66-1.21, fixed effects model). The analysis on any lymphoma did not reach statistical significance (OR = 1.10, 95% CI = 0.96-1.27, fixed effects model), possibly because of the case-mix of NHL to HL. No dose-response association was revealed in the metaregression analysis. In conclusion, this meta-analysis points to a modest increase in the risk for childhood NHL, but not HL, among children born by mothers smoking during pregnancy. Further investigation of dose-response phenomena in the NHL association, however, warrants accumulation of additional data.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1002/ijc.25929-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21225624-
heal.journalNameInt J Canceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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