The relationship between adiponectin, an adiponectin gene polymorphism, and high-density lipoprotein particle size: from the Mima study
| dc.contributor.author | Tsuzaki, K. | en |
| dc.contributor.author | Kotani, K. | en |
| dc.contributor.author | Sano, Y. | en |
| dc.contributor.author | Fujiwara, S. | en |
| dc.contributor.author | Gazi, I. F. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.contributor.author | Sakane, N. | en |
| dc.date.accessioned | 2015-11-24T19:32:36Z | |
| dc.date.available | 2015-11-24T19:32:36Z | |
| dc.identifier.issn | 1532-8600 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23431 | |
| dc.rights | Default Licence | - |
| dc.title | The relationship between adiponectin, an adiponectin gene polymorphism, and high-density lipoprotein particle size: from the Mima study | en |
| heal.abstract | This study examined the association among serum adiponectin levels, a single nucleotide polymorphism (SNP) of the adiponectin gene, and the size of serum high-density lipoprotein (HDL) particles in a general population. A total of 275 subjects were examined as part of the community-based Mima study. Serum adiponectin levels were measured with an enzyme-linked immunosorbent assay. Serum small-sized HDL was measured with the electrophoretic separation of lipoproteins using the Lipoprint system. Single nucleotide polymorphism G276T (rs1501299, SNP276) of the adiponectin gene was determined with a fluorescent allele-specific DNA primer assay system. Age- and sex-adjusted correlation test revealed a significant inverse relationship between small-sized HDL and adiponectin levels (r = -0.236, P < .001). More percentages of small-sized HDL were observed in the subjects with the SNP276 G/G and G/T genotypes than in those with the T/T genotype (5.5% +/- 5.0% vs 3.0% +/- 2.9%, P = .016). In a multiple regression analysis, small-sized HDL was significantly and independently correlated with triglycerides levels (beta = 0.133, P = .030), adiponectin levels (beta = -0.242, P < .001), and the SNP276 G allele (beta = -0.142, P = .014). Our findings indicated that adiponectin and SNP276 of the adiponectin gene may modify the size of HDL particles. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.metabol.2011.06.021 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21820140 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0026049511002010/1-s2.0-S0026049511002010-main.pdf?_tid=20d325f6eeab053a4203126ed7f5e8a7&acdnat=1333539045_efaf1fe251d3ef9e52ac0d1e4bf55981 | - |
| heal.journalName | Metabolism | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2012 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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