Impact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndrome

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dc.contributor.authorMilionis, H. J.en
dc.contributor.authorKostapanos, M. S.en
dc.contributor.authorVakalis, K.en
dc.contributor.authorTheodorou, I.en
dc.contributor.authorBouba, I.en
dc.contributor.authorKalaitzidis, R.en
dc.contributor.authorGeorgiou, I.en
dc.contributor.authorElisaf, M. S.en
dc.contributor.authorSiamopoulos, K. C.en
dc.date.accessioned2015-11-24T19:11:39Z
dc.date.available2015-11-24T19:11:39Z
dc.identifier.issn1470-3203-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20948
dc.rightsDefault Licence-
dc.subjectDemographyen
dc.subjectFemaleen
dc.subjectGenotypeen
dc.subjectGreece/epidemiologyen
dc.subjectHumansen
dc.subjectHypertension/*complications/*drug therapy/geneticsen
dc.subjectMaleen
dc.subjectMetabolic Syndrome X/*complications/*drug therapy/epidemiology/geneticsen
dc.subjectMiddle Ageden
dc.subjectPolymorphism, Geneticen
dc.subjectPrevalenceen
dc.subjectRegression Analysisen
dc.subjectRenin-Angiotensin System/*geneticsen
dc.subjectTreatment Outcomeen
dc.titleImpact of renin-angiotensin-aldosterone system genes on the treatment response of patients with hypertension and metabolic syndromeen
heal.abstractOBJECTIVE: To evaluate the influence of clinical, biochemical and genetic markers on the response to antihypertensive treatment in patients with essential hypertension and the metabolic syndrome (MetS). METHODS: Measurements of anthropometric indices, blood pressure (BP), and metabolic parameters were obtained from the medical records of 132 (77 women) newly diagnosed, untreated hypertensive patients. Renin-angiotensin-aldosterone system (RAAS) genes polymorphisms (including ACE I/D, angiotensinogen M235T, angiotensin II type 1 receptor [AT1-receptor] A1166C) were determined. Response to treatment was defined as BP less than 140/90 mmHg. RESULTS: Patients with MetS (n=60) had higher systolic BP and pulse pressure and a more atherogenic lipid profile than patients without MetS. The frequencies of the ACE and the AT1-receptor gene polymorphisms were similar between patients with and without MetS. Response to treatment was positively associated with pulse pressure, and the presence of the C allele as well as the AC genotype of the AT1-receptor gene and inversely with age after adjustment for confounding factors. CONCLUSIONS: RAAS genes distribution does not differ between hypertensive patients with and without the MetS. Higher baseline pulse pressure levels, the presence of the C allele and/or the AC genotype may be in favour of a better response to structured antihypertensive treatment in patients with MetS. However, these findings need to be evaluated in future studies.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.3317/jraas.2007.027-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18205097-
heal.identifier.secondaryhttp://jra.sagepub.com/content/8/4/181.full.pdf-
heal.journalNameJ Renin Angiotensin Aldosterone Systen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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