Postoperative levels of cardiac troponin versus CK-MB and high-sensitivity C-reactive protein for the prediction of 1-year cardiovascular outcome in patients undergoing vascular surgery

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dc.contributor.authorKouvelos, G. N.en
dc.contributor.authorMilionis, H. J.en
dc.contributor.authorArnaoutoglou, E. M.en
dc.contributor.authorChasiotis, G.en
dc.contributor.authorGartzonika, C.en
dc.contributor.authorPapa, N. K.en
dc.contributor.authorTzimas, P.en
dc.contributor.authorMatsagkas, M. I.en
dc.date.accessioned2015-11-24T18:57:34Z
dc.date.available2015-11-24T18:57:34Z
dc.identifier.issn1473-5830-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19186
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectBiological Markers/blooden
dc.subjectC-Reactive Protein/*analysisen
dc.subjectCardiovascular Diseases/blood/diagnosis/etiology/mortalityen
dc.subjectChi-Square Distributionen
dc.subjectCreatine Kinase, MB Form/*blooden
dc.subjectDisease-Free Survivalen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectKaplan-Meier Estimateen
dc.subjectLogistic Modelsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPredictive Value of Testsen
dc.subjectProspective Studiesen
dc.subjectROC Curveen
dc.subjectRisk Assessmenten
dc.subjectRisk Factorsen
dc.subjectSensitivity and Specificityen
dc.subjectSurgical Procedures, Electiveen
dc.subjectTime Factorsen
dc.subjectTreatment Outcomeen
dc.subjectTroponin I/*blooden
dc.subjectVascular Surgical Procedures/*adverse effects/mortalityen
dc.titlePostoperative levels of cardiac troponin versus CK-MB and high-sensitivity C-reactive protein for the prediction of 1-year cardiovascular outcome in patients undergoing vascular surgeryen
heal.abstractOBJECTIVE: This study evaluated comparatively the predictive value of postoperative cardiac troponin I (cTnI), creatinine kinase (CK)-MB, and high-sensitivity C-reactive protein (hs-CRP) in 1-year cardiovascular mortality and morbidity in patients undergoing elective vascular surgery. METHODS: A total of 295 consecutive patients undergoing elective noncardiac vascular surgery were prospectively followed-up over a period of 12 months. The levels of cTnI, CK-MB, and hs-CRP were measured preoperatively and 24 h after operation. The primary endpoint was the composite of cardiovascular death, nonfatal acute myocardial infarction, ischemic stroke, and unstable angina. RESULTS: The primary endpoints occurred in 11 patients (3.8%). Receiver operating characteristic curve analysis showed that postoperative cTnI was a strong predictor of a cardiovascular event during 1-year follow-up (area under the curve, 0.852; P<0.001). Areas under the curve for hs-CRP and for CK-MB were 0.734 (P=0.008) and 0.494 (P=0.947). A threshold cTnI value of 0.4 ng/ml was highly associated with the occurrence of a cardiovascular event, with a sensitivity of 80% and specificity of 81%. Furthermore, cTnI levels provided a significantly better prediction than CK-MB levels (P=0.009) and tended to be superior to hs-CRP (P=0.2). CONCLUSION: Postoperative cTnI levels seem to be superior to CK-MB and hs-CRP levels for the prediction of 1-year cardiovascular mortality and morbidity in patients undergoing elective vascular surgery.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1097/MCA.0b013e3283487d96-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21730823-
heal.journalNameCoron Artery Disen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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