Non small cell lung cancer in the elderly: clinico-pathologic, management and outcome characteristics in comparison to younger patients

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dc.contributor.authorKoumarianou, A.en
dc.contributor.authorFountzilas, G.en
dc.contributor.authorKosmidis, P.en
dc.contributor.authorKlouvas, G.en
dc.contributor.authorSamantas, E.en
dc.contributor.authorKalofonos, C.en
dc.contributor.authorPentheroudakis, G.en
dc.contributor.authorEconomopoulos, T.en
dc.contributor.authorPectasides, D.en
dc.date.accessioned2015-11-24T19:01:53Z
dc.date.available2015-11-24T19:01:53Z
dc.identifier.issn1973-9478-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19736
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/mortality/pathology/*therapyen
dc.subjectAge Factorsen
dc.subjectAgeden
dc.subjectAntineoplastic Combined Chemotherapy Protocols/*therapeutic useen
dc.subjectCarcinoma, Large Cell/mortality/secondary/*therapyen
dc.subjectCarcinoma, Non-Small-Cell Lung/mortality/secondary/*therapyen
dc.subjectCarcinoma, Squamous Cell/mortality/secondary/*therapyen
dc.subjectChemotherapy, Adjuvanten
dc.subjectCohort Studiesen
dc.subjectCombined Modality Therapyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLung Neoplasms/mortality/pathology/*therapyen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Stagingen
dc.subjectPrognosisen
dc.subjectRadiotherapy, Adjuvanten
dc.subjectRegistriesen
dc.subjectSurvival Rateen
dc.subjectTreatment Outcomeen
dc.titleNon small cell lung cancer in the elderly: clinico-pathologic, management and outcome characteristics in comparison to younger patientsen
heal.abstractIt is controversial whether non-small cell lung cancer (NSCLC) in the elderly constitutes a distinct clinico-biological entity compared to younger counterparts. As reported data are scant and discordant, we sought to analyze retrospectively the medical records of Hellenic NSCLC patients aged >70 years and compare them with those of age (70-45 years) and younger (<45 years) patients. Records were abstracted from the Hellenic Cooperative Oncology Group (HeCOG) cancer registry database. Presentation, management and outcome data of 417 elderly patients aged > or =70, 1374 age 70-45 years old and 115 patients aged < or =45 years old with histologically confirmed NSCLC managed from 1989 until 2004 were retrieved and compared. Elderly patients differed significantly in terms of presence of symptoms (p<0.001), including thoracic pain (p=0.003), dyspnea (p<0.001), cough (p<0.001) and fatigue (p<0.001), eastern Cooperative Oncology Group performance status (PS) 2-3 (p<0.001), and histological type (more commonly diagnosed with squamous cell carcinoma (p<0.002) and less frequently with adenocarcinoma). Although elderly patients had significantly higher rates of PS 2-3, they had significantly better median time to disease progression (TTP) compared to the younger counterpart (6.4 versus 4.3 months p=0.047). Overall survival (OS) was not significantly different between elderly and young patients (median OS 11.8 versus 11.5 months; p=0.6), but platinum-based chemotherapy and radiotherapy were variables associated favorably with TTP and survival in the elderly. This large retrospective series presents strong evidence that NSCLC constitutes a similar clinicopathologic entity in elderly and young individuals with discretely differing biological behavior and that elderly symptomatic patients should be considered for effective anticancer treatment whenever possible.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19933050-
heal.journalNameJ Chemotheren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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