Systematic review: hepatic fibrosis - regression with therapy
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Ημερομηνία
Συγγραφείς
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Aliment Pharmacol Ther
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Hepatic fibrosis occurs in response to chronic liver injury, regardless of the cause. An impressive amount of knowledge concerning the pathogenesis and treatment of liver fibrosis has emerged over the past few years. The hallmark of this event is the activation of the hepatic stellate cell. The latter event causes accumulation of extracellular matrix and formation of scar, leading to deterioration in hepatic function. AIM: To assess chronic liver injury, many invasive and non-invasive methods have been suggested. METHODS: Although transient elastography, image analysis of fractal geometry and fibrotest with actitest have been used in clinical practice, liver biopsy remains the recommended choice, especially when histological staging of fibrosis or response to treatment is needed. CONCLUSIONS: The recent advances in anti-viral therapy have resulted in many reports on fibrosis and even on cirrhosis regression, especially early and in young people. A number of new agents have been suggested for the treatment of fibrosis, with promising results in animals; however, their efficacy in humans remains to be elucidated. The investigation of heterogeneity and plasticity of hepatic stellate cells is a topic of scientific interest and may result in improvements in patient management.
Περιγραφή
Λέξεις-κλειδιά
Biological Markers, Disease Progression, Extracellular Matrix/*physiology, Humans, Liver Cirrhosis/diagnosis/pathology/*therapy, Remission Induction/methods
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18761707
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2036.2008.03840.x/asset/j.1365-2036.2008.03840.x.pdf?v=1&t=h0oxapds&s=808b15a3a2c4d9618d150f08e826b633bb6344ca
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2036.2008.03840.x/asset/j.1365-2036.2008.03840.x.pdf?v=1&t=h0oxapds&s=808b15a3a2c4d9618d150f08e826b633bb6344ca
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής