Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency

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dc.contributor.authorO'Halloran, D. J.en
dc.contributor.authorTsatsoulis, A.en
dc.contributor.authorWhitehouse, R. W.en
dc.contributor.authorHolmes, S. J.en
dc.contributor.authorAdams, J. E.en
dc.contributor.authorShalet, S. M.en
dc.date.accessioned2015-11-24T19:10:53Z
dc.date.available2015-11-24T19:10:53Z
dc.identifier.issn0021-972X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20879
dc.rightsDefault Licence-
dc.subjectAdipose Tissue/drug effectsen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectBone Density/*drug effectsen
dc.subjectDouble-Blind Methoden
dc.subjectFemaleen
dc.subjectGrowth Hormone/*deficiency/*therapeutic useen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMuscles/drug effects/pathologyen
dc.subjectPlacebosen
dc.subjectRecombinant Proteinsen
dc.subjectSpine/drug effects/radiographyen
dc.subjectThighen
dc.subjectTime Factorsen
dc.subjectTomography, X-Ray Computeden
dc.titleIncreased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiencyen
heal.abstractThe physiological role of GH in the adult skeleton is unknown. In this study, 12 adults (10 males and 2 females) with isolated GH deficiency were treated with GH as a single daily sc injection (0.125 IU/kg.week for the first 4 weeks and subsequently at 0.25 IU/kg.week) for 1 yr in a double blind, placebo-controlled manner. Bone mineral density of the spine (T12-L3) was measured by quantitative computed tomography, and bone mineral content (BMC) of the forearm by single photon absorptiometry at entry into the study and subsequently at 6 monthly intervals. All baseline bone mineral measurements were reduced compared with those in an age- and sex-matched control population. In the treatment cohort, quantitative computed tomography spinal trabecular bone mineral density increased by 7.8 g/L after 6 months of GH replacement (mean +/- SEM, 151.7 +/- 6.0 vs. 159.5 +/- 5.9 g/L; n = 11; P < 0.01), and this increment was maintained at 1 yr (160.7 +/- 6.3 g/L). Proximal forearm (cortical) BMC showed no change after 6 months of GH replacement, but there was a significant increase of 0.06 g/cm after 12 months of GH replacement (from 1.38 +/- 0.04 to 1.44 +/- 0.04 g/cm; n = 12; P < 0.05). Distal forearm (cortical and trabecular) BMC also increased significantly during the study period from 1.46 +/- 0.04 g/cm to 1.52 +/- 0.05 g/cm; n = 12, P < 0.05. No significant changes occurred in bone mineral measurements during 6 months of placebo therapy. Midthigh muscle and fat cross-sectional area increased and decreased, respectively, during the active treatment phase. These results demonstrate that GH plays an important role in maintaining the integrity of the adult skeleton.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8496328-
heal.identifier.secondaryhttp://jcem.endojournals.org/content/76/5/1344-
heal.journalNameJ Clin Endocrinol Metaben
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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