Could X-ray microbeams inhibit angioplasty-induced restenosis in the rat carotid artery?
Φόρτωση...
Ημερομηνία
Συγγραφείς
Dilmanian, F. A.
Kalef-Ezra, J.
Petersen, M. J.
Bozios, G.
Vosswinkel, J.
Giron, F.
Ren, B.
Yakupov, R.
Antonakopoulos, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Cardiovasc Radiat Med
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Parallel, thin (<100 microm) planes of synchrotron-generated X rays, have been shown to spare normal tissues and preferentially damage tumors in animal models. The aim of the present study was to assess the effect of such microbeams directed unidirectionally on angioplasted rat carotid arteries. METHODS AND MATERIALS: Three groups of Sprague-Dawley rats were studied: (a) rats with normal, untreated arteries, (b) rats treated by balloon angioplasty, but not irradiated, and (c) rats treated with balloon angioplasty and exposed to single fraction, unidirectional, parallel, microbeams an hour after angioplasty. The microbeam array, 15 mm widex7.6 mm high, consisting of 27-microm-wide beam slices, spaced 200 microm center-to-center laterally traversed the damaged artery. The in-depth in-beam dose was 150 Gy, the "valley" dose (dose midway between microbeams resulting mainly from X-ray scattering) was 4.5 Gy on average, and the "integrated" (averaged) dose was 26 Gy. RESULTS: Microbeam irradiation, as given in the present study, was tolerated, but was insufficient to significantly suppress the neointimal hyperplasia. DISCUSSION: The microbeam dose used is considered low. Dose escalation would be necessary to reach conclusive results regarding the X-ray microbeam efficacy to control restenosis.
Περιγραφή
Λέξεις-κλειδιά
Angioplasty, Balloon/*adverse effects, Animals, Carotid Artery, Common/*pathology/radiation effects/*surgery, Carotid Stenosis/*therapy, Disease Models, Animal, Dose-Response Relationship, Radiation, Graft Occlusion, Vascular/*etiology/*radiotherapy, Hyperplasia/etiology/radiotherapy, Models, Cardiovascular, Rats, Rats, Sprague-Dawley, Tunica Intima/pathology/radiation effects, X-Rays
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/14984714
http://ac.els-cdn.com/S152218650300180X/1-s2.0-S152218650300180X-main.pdf?_tid=21f24bcc7ec77af1f3a3d27fa9e17420&acdnat=1333088136_78b2e4409f4104eb3323a871591e6dab
http://ac.els-cdn.com/S152218650300180X/1-s2.0-S152218650300180X-main.pdf?_tid=21f24bcc7ec77af1f3a3d27fa9e17420&acdnat=1333088136_78b2e4409f4104eb3323a871591e6dab
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής