Severity of cardiovascular disease in postmenopausal women: associations with common estrogen receptor alpha polymorphic variants

dc.contributor.authorAlevizaki, M.en
dc.contributor.authorSaltiki, K.en
dc.contributor.authorCimponeriu, A.en
dc.contributor.authorKanakakis, I.en
dc.contributor.authorXita, N.en
dc.contributor.authorAlevizaki, C. C.en
dc.contributor.authorGeorgiou, I.en
dc.contributor.authorSarika, H. L.en
dc.date.accessioned2015-11-24T18:51:50Z
dc.date.available2015-11-24T18:51:50Z
dc.identifier.issn0804-4643-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18316
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAllelesen
dc.subjectBirth Rateen
dc.subjectCardiovascular Diseases/*genetics/*radiographyen
dc.subject*Coronary Angiographyen
dc.subjectEstrogen Receptor alpha/*geneticsen
dc.subjectFemaleen
dc.subject*Genetic Predisposition to Diseaseen
dc.subjectGenotypeen
dc.subjectHomozygoteen
dc.subjectHumansen
dc.subjectInsulin/blooden
dc.subjectMiddle Ageden
dc.subject*Polymorphism, Geneticen
dc.subject*Postmenopauseen
dc.subjectSeverity of Illness Indexen
dc.subjectTriglycerides/blooden
dc.titleSeverity of cardiovascular disease in postmenopausal women: associations with common estrogen receptor alpha polymorphic variantsen
heal.abstractOBJECTIVE: Impaired estrogen action is a risk factor for coronary artery disease (CAD). Associations of CAD with estrogen receptor alpha (ER alpha) polymorphisms, which may influence sensitivity to estrogen, have been reported for men; the data concerning women are not conclusive. We investigated the association of common ER alpha polymorphisms with the severity of CAD and with metabolic and reproductive factors in postmenopausal women undergoing coronary angiography. METHODS: ER alpha polymorphisms at positions c.454-397 T>C (PvuII) and c.454-351 A>G (XbaI) were studied in 157 women (age 45-88 years). The severity of CAD was assessed by the number of arteries with >50% stenosis in the angiography. RESULTS: There was a significant association between the TT, TC, and CC genotypes (PvuII) and the severity of CAD (P=0.008); similar results were obtained for the XbaI polymorphism (P=0.021). These associations were independent of other risk factors for CAD. Women homozygous for the C allele had significantly higher triglyceride and insulin levels; they belonged more frequently to the group with a low number of births (n</=1; P=0.014, Fisher's exact). CONCLUSIONS: Common ER alpha polymorphisms may influence the severity of CAD in women undergoing coronary angiography, reflecting lifetime exposure to estrogen. Similar associations have been reported for men with CAD. These polymorphisms should probably be taken into account when associations with estrogenic actions are examined.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1530/EJE-06-0685-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17389465-
heal.identifier.secondaryhttp://www.eje-online.org/content/156/4/489.full.pdf-
heal.journalNameEur J Endocrinolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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