The effects of propofol or sevoflurane on free radical production after tourniquet induced ischaemia-reperfusion injury during knee arthroplasty

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dc.contributor.authorArnaoutoglou, H.en
dc.contributor.authorVretzakis, G.en
dc.contributor.authorSouliotis, D.en
dc.contributor.authorCambili, M.en
dc.contributor.authorGalaris, D.en
dc.contributor.authorPapadopoulos, G.en
dc.date.accessioned2015-11-24T19:41:38Z
dc.date.available2015-11-24T19:41:38Z
dc.identifier.issn0001-5164-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24514
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAnalysis of Varianceen
dc.subjectAnesthetics, Inhalation/*pharmacologyen
dc.subjectAnesthetics, Intravenous/*pharmacologyen
dc.subjectArthroplasty, Replacement, Kneeen
dc.subjectFemaleen
dc.subjectFree Radicals/metabolismen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMalondialdehyde/*blooden
dc.subjectMethyl Ethers/*pharmacologyen
dc.subjectOxidative Stress/*drug effectsen
dc.subjectPropofol/*pharmacologyen
dc.subjectReperfusion Injury/etiology/metabolismen
dc.subjectTourniquetsen
dc.titleThe effects of propofol or sevoflurane on free radical production after tourniquet induced ischaemia-reperfusion injury during knee arthroplastyen
heal.abstractBACKGROUND: We studied the effects of anesthesia with propofol or sevoflurane on the production of free oxygen radicals during total knee arthroplasty performed with the use of an ischemic tourniquet by measuring the levels of malondialdehyde (MDA). METHODS: We studied two groups of patients (20 patients in each group) who underwent total knee arthroplasty. To maintain anesthesia we delivered 66% nitrous oxide plus sevoflurane or propofol. Blood samples for the determination of the MDA levels were drawn before the application of the ischemic tourniquet and 5 and 30 minutes after its release. RESULTS: There were no differences between groups in regard to age, weight and duration of the tourniquet application. MDA levels decreased significantly in the propofol group 30 minutes after the release of the tourniquet (1.7 micromol litre(-1) vs 1.57 micromol litre(-1), Friedman's ANOVA, P = 0.007). In contrast, there was a small rise of the MDA levels in the sevoflurane group (1.82 micromol litre(-1) vs 1.96 micromol litre(-1), Friedman's ANOVA, P = 0.007). CONCLUSION: Propofol may have anti-oxidant properties in orthopaedic surgery requiring tourniquet application, but sevoflurane needs further study.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17486917-
heal.journalNameActa Anaesthesiol Belgen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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