Immunohistochemical study of angiogenesis and proliferative activity in epiretinal membranes

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dc.contributor.authorTsanou, E.en
dc.contributor.authorIoachim, E.en
dc.contributor.authorStefaniotou, M.en
dc.contributor.authorGorezis, S.en
dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorBagli, H.en
dc.contributor.authorPeschos, D.en
dc.contributor.authorPsilas, K.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:11:51Z
dc.date.available2015-11-24T19:11:51Z
dc.identifier.issn1368-5031-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20969
dc.rightsDefault Licence-
dc.subjectCell Proliferationen
dc.subjectDiabetic Retinopathy/metabolism/pathologyen
dc.subjectEpiretinal Membrane/metabolism/*pathologyen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectKi-67 Antigen/metabolismen
dc.subjectRetinal Neovascularization/metabolism/*pathologyen
dc.subjectVascular Endothelial Growth Factor A/metabolismen
dc.subjectVitreoretinopathy, Proliferative/metabolism/pathologyen
dc.titleImmunohistochemical study of angiogenesis and proliferative activity in epiretinal membranesen
heal.abstractFormation of epiretinal membranes (ERMs) is a serious complication of retinal diseases, the most important being proliferative diabetic retinopathy (PDR) and proliferative vitreoretinopathy (PVR). In this study, our goal was to (i) calculate the microvessel density (MVD), (ii) evaluate vascular endothelial growth factor (VEGF) expression and (iii) correlate angiogenesis with the proliferative activity as expressed by the expression of Ki67 marker, in both membrane types. We performed immunohistochemistry in 14 PVR and eight PDR membranes, using antibodies against CD34, VEGF, Ki67 and glial fibrillary acidic protein. PDR membranes presented higher average count of microvessels compared with PVR membranes (p = 0.0015). No differences were observed concerning VEGF expression (p = 0.1). The expression of Ki67 was not correlated with microvessel number or VEGF expression. Our study confirms the presence of vascularisation in PDR membranes, as well as the presence of VEGF even in avascular PVR membranes, suggesting that immunoreactivity for VEGF may not be accompanied by angiogenesis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1368-5031.2005.00573.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16178982-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1368-5031.2005.00573.x/asset/j.1368-5031.2005.00573.x.pdf?v=1&t=h2lhbhl8&s=5884eac16ebeecb2ca86088b6aecc1e8a5c056ba-
heal.journalNameInt J Clin Practen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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