Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis
| dc.contributor.author | Panoulas, V. F. | en |
| dc.contributor.author | Douglas, K. M. | en |
| dc.contributor.author | Smith, J. P. | en |
| dc.contributor.author | Metsios, G. S. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.contributor.author | Nightingale, P. | en |
| dc.contributor.author | Kitas, G. D. | en |
| dc.date.accessioned | 2015-11-24T19:15:10Z | |
| dc.date.available | 2015-11-24T19:15:10Z | |
| dc.identifier.issn | 1525-6006 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21467 | |
| dc.rights | Default Licence | - |
| dc.subject | Aged | en |
| dc.subject | Arthritis, Rheumatoid/complications/*genetics | en |
| dc.subject | Blood Pressure | en |
| dc.subject | Female | en |
| dc.subject | Galectin 2/*genetics | en |
| dc.subject | Genotype | en |
| dc.subject | Humans | en |
| dc.subject | Hypertension/complications/*genetics | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Myocardial Infarction/complications/*genetics | en |
| dc.subject | *Polymorphism, Single Nucleotide | en |
| dc.subject | Prevalence | en |
| dc.subject | Risk Factors | en |
| dc.title | Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis | en |
| heal.abstract | The galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1080/10641960802621267 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19330599 | - |
| heal.identifier.secondary | http://informahealthcare.com/doi/abs/10.1080/10641960802621267 | - |
| heal.journalName | Clin Exp Hypertens | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2009 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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