Phase II study of 5-fluorouracil and interferon-gamma in patients with metastatic colorectal cancer. A Hellenic Cooperative Oncology Group Study
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Authors
Pavlidis, N.
Nicolaides, C.
Athanassiadis, A.
Beriatou, K.
Skarlos, D.
Giannakakis, T.
Kosmidis, P.
Karvounis, N.
Fountzilas, G.
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peer-reviewed
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Oncology
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Preclinical data have shown a synergism between 5-fluorouracil and interferon-gamma against human colon carcinoma cell lines. We conducted a phase II trial of this combination in 34 patients with metastatic colorectal cancer. 5-Fluorouracil was administered as an intravenous bolus of 500 mg/m2 weekly and interferon-gamma subcutaneous injection at a dose of 200 micrograms (6 x 10(6) IU) 3 times a week. Thirty-two patients were evaluable for response. There was one complete and two partial responses (response rate 9.0%, 95% CI 1.98-25.02%). Eleven patients (34%) had stable disease. Common toxicities included fever 81%, nausea/vomiting 19%, diarrhea 16%, flu-like syndrome 16%, malaise 12.5% and leukopenia 12.5%. These results indicate that the above combination of 5-fluorouracil and interferon-gamma has an unimpressive activity in patients with advanced colorectal carcinoma. Toxicity was very tolerable.
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Keywords
Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use, Colorectal Neoplasms/*drug therapy, Female, Fluorouracil/administration & dosage/adverse effects, Humans, Interferon-gamma/administration & dosage/adverse effects, Male, Middle Aged, Neoplasm Metastasis, Prospective Studies, Treatment Outcome
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http://www.ncbi.nlm.nih.gov/pubmed/8604243
http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000227553
http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000227553
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής