Homophily and co-occurrence patterns shape randomized trials agendas: illustration in antifungal agents
Φόρτωση...
Ημερομηνία
Συγγραφείς
Rizos, E. C.
Salanti, G.
Kontoyiannis, D. P.
Ioannidis, J. P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Clin Epidemiol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: To assess whether there are preferences and avoidances for specific comparisons in a clinical trials agenda. STUDY DESIGN AND SETTING: We tested for homophily (preference to compare agents against others in the same class) and co-occurrence (preference or avoidance of specific head-to-head comparisons) in the randomized trials agenda of antifungal agents. We searched MEDLINE and Cochrane Library databases for English language randomized trials evaluating systemic antifungals against Candida or Aspergillus in adults. We extracted data on compared regimens, sample size, publication year, indication (treatment/prophylaxis), and underlying disease. RESULTS: One hundred forty-four trials (74 treatments, 70 prophylaxes) were found (n=27,497 patients). Among polyene and azole groups, agents were compared within the same class more often than across classes (homophily test P<0.001). Lipid amphotericin was compared almost entirely against conventional amphotericin (18 trials), with only three comparisons against azoles. Head-to-head comparisons of newer agents were avoided. Only one of 14 trials for echinocandins compared head-to-head two different echinocandins (P<0.001 for co-occurrence). Of 11 trials on newer azoles, only one compared a newer azole with an echinocandin (P<0.001 for co-occurrence). CONCLUSIONS: Trial networks for antifungals show that specific comparisons are preferred and others avoided, generating a potentially biased clinical research agenda.
Περιγραφή
Λέξεις-κλειδιά
Antifungal Agents/*standards/therapeutic use, Drug Information Services/*standards, Humans, Mycoses/*drug therapy, *Randomized Controlled Trials as Topic
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21411286
http://ac.els-cdn.com/S0895435610004300/1-s2.0-S0895435610004300-main.pdf?_tid=f5817c48e0388747a6b51dbcfcd12bdd&acdnat=1333018162_3df84aa39b6c92bec2580181572c736d
http://ac.els-cdn.com/S0895435610004300/1-s2.0-S0895435610004300-main.pdf?_tid=f5817c48e0388747a6b51dbcfcd12bdd&acdnat=1333018162_3df84aa39b6c92bec2580181572c736d
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής