Expression of the extracellular matrix protein tenascin in laryngeal epithelial lesions: correlation with fibronectin, CD44, cathepsin D and proliferation indices

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dc.contributor.authorGoussia, A. C.en
dc.contributor.authorIoachim, E. E.en
dc.contributor.authorPeschos, D.en
dc.contributor.authorAssimakopoulos, D. A.en
dc.contributor.authorSkevas, A.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:16:33Z
dc.date.available2015-11-24T19:16:33Z
dc.identifier.issn0945-6317-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21678
dc.rightsDefault Licence-
dc.subjectAntigens, CD44/analysisen
dc.subjectCathepsin D/analysisen
dc.subjectEpithelium/pathologyen
dc.subjectFibronectins/analysisen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectLaryngeal Diseases/*pathologyen
dc.subjectLaryngeal Neoplasms/chemistry/*pathologyen
dc.subjectPrecancerous Conditions/chemistry/*pathologyen
dc.subjectProliferating Cell Nuclear Antigen/analysisen
dc.subjectTenascin/*analysisen
dc.titleExpression of the extracellular matrix protein tenascin in laryngeal epithelial lesions: correlation with fibronectin, CD44, cathepsin D and proliferation indicesen
heal.abstractTenascin (TN) is an extracellular matrix glycoprotein expressed in areas of epithelial-mesenchymal interactions during embryogenesis and in neoplasia. We studied the expression of TN in a series of 35 squamous cell invasive carcinomas of the larynx, 13 in situ carcinomas, 41 cases of dysplasia, 10 papillomas and 18 cases of keratosis using the monoclonal antibody TN2 on paraffin-embedded tissue. TN expression was correlated with the expression of fibronectin, CD44 and cathepsin D (CD) proteins, with the proliferation indices Ki-67 and proliferating cell nuclear antigen (PCNA) as well as with conventional clinicopathological variables. Malignant tumours showed a significantly greater stromal TN staining than benign lesions. In invasive carcinomas, the immunoreactivity was statistically higher than that in situ (P=0.01), dysplastic lesions (P<0.0001), papillomas (P=0.004) and keratosis (P<0.0001). A statistically significant difference of TN expression between in situ and dysplastic lesions was observed (P=0.001). In invasive lesions, TN expression was statistically correlated with CD44 expression (P=0.02) and a trend for correlation with CD of tumour cells and fibronectin expression was found (P=0.06 and P=0.09, respectively). The relationship of TN expression with the histological grade and the proliferative activity was insignificant. In conclusion, stromal TN expression may be involved in the complex mechanism of development of laryngeal lesions and may help to predict the risk of progression of pre-cancerous lesions to cancer.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10917172-
heal.identifier.secondaryhttp://www.springerlink.com/content/5dw9etrb5kc4dxwv/fulltext.pdf-
heal.journalNameVirchows Archen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2000-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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