Leptospirosis is Associated with Markedly Increased Triglycerides and Small Dense Low-Density Lipoprotein and Decreased High-Density Lipoprotein

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dc.contributor.authorGazi, I. F.en
dc.contributor.authorApostolou, F.en
dc.contributor.authorLiberopoulos, E. N.en
dc.contributor.authorFilippatos, T. D.en
dc.contributor.authorTellis, C. C.en
dc.contributor.authorElisaf, M. S.en
dc.contributor.authorTselepis, A. D.en
dc.date.accessioned2015-11-24T16:41:00Z
dc.date.available2015-11-24T16:41:00Z
dc.identifier.issn0024-4201-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8348
dc.rightsDefault Licence-
dc.subjectleptospiraen
dc.subjectlipidsen
dc.subjectlipoproteinsen
dc.subjectcytokinesen
dc.subjectsdldlen
dc.subjectldl particle sizeen
dc.subjectplatelet-activating-factoren
dc.subjectserum paraoxonase-1 activityen
dc.subjectacute-phase responseen
dc.subjectimmunodeficiency-virus-infectionen
dc.subjectacute-renal-failureen
dc.subjectfactor-acetylhydrolaseen
dc.subjectphospholipase a(2)en
dc.subjectpaf-acetylhydrolaseen
dc.subjectplasmaen
dc.subjectsepsisen
dc.titleLeptospirosis is Associated with Markedly Increased Triglycerides and Small Dense Low-Density Lipoprotein and Decreased High-Density Lipoproteinen
heal.abstractThe objective of the present study was to evaluate the effects of acute infection with Leptospira interrogans on lipids, lipoproteins and associated enzymes. Fasting serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), apolipoproteins (apo) A-I (TM), B, E, C-II, C-III and lipoprotein (a) [Lp(a)] were determined in patients with Leptospirosis on diagnosis and 4 months after recovery as well as in age- and sex-matched controls. Activities of cholesteryl-ester transfer protein (CETP) and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) as well as paraoxonase 1 (PON1) hydrolysing activity and levels of cytokines were determined. LDL subclass analysis was performed with Lipoprint LDL System. Eleven patients (10 men, mean age 49.5 +/- A 8.4 years) and 11 controls were included. TC, HDL-C, LDL-C, apoA-I, apoB and Lp(a) levels were lower at baseline, whereas TG and apoE levels were elevated compared with 4 months later. At baseline, higher levels of cytokines and cholesterol concentration of small dense LDL particles (sdLDL-C) were noticed, whereas LDL particle size was lower compared with follow-up. Activities of plasma Lp-PLA(2) and HDL-associated Lp-PLA(2) were lower at baseline compared with post treatment values, whereas PON1 activity was similar at baseline and 4 months later. 4 months after recovery, the levels of all lipid parameters evaluated did not differ compared with controls, except for HDL-C which remained lower. PON1 activity both at baseline and 4 months later was lower in patients compared with controls. Leptospirosis is associated with atherogenic changes of lipids, lipoproteins and associated enzymes.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1007/s11745-011-3580-y-
heal.identifier.secondary<Go to ISI>://000294562700007-
heal.identifier.secondaryhttp://www.springerlink.com/content/cx2k588685vqmnu5/fulltext.pdf-
heal.journalNameLipidsen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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