New antimony(III) bromide complexes with thioamides: synthesis, characterization, and cytostatic properties

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dc.contributor.authorOzturk, IIen
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorHadjiliadis, N.en
dc.contributor.authorKourkoumelis, N.en
dc.contributor.authorKubicki, M.en
dc.contributor.authorTasiopoulos, A. J.en
dc.contributor.authorScleiman, H.en
dc.contributor.authorBarsan, M. M.en
dc.contributor.authorButler, I. S.en
dc.contributor.authorBalzarini, J.en
dc.date.accessioned2015-11-24T19:02:08Z
dc.date.available2015-11-24T19:02:08Z
dc.identifier.issn1520-510X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19766
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAntimony/*chemistryen
dc.subjectBromides/*chemistryen
dc.subjectCell Line, Tumoren
dc.subjectCell Proliferation/drug effectsen
dc.subjectComputer Simulationen
dc.subjectCrystallography, X-Rayen
dc.subjectCytostatic Agents/*chemical synthesis/chemistry/*pharmacologyen
dc.subjectHumansen
dc.subjectModels, Molecularen
dc.subjectOrganometallic Compounds/*chemical synthesis/chemistry/*pharmacologyen
dc.subjectThioamides/*chemistryen
dc.titleNew antimony(III) bromide complexes with thioamides: synthesis, characterization, and cytostatic propertiesen
heal.abstractNew antimony(III) bromide complexes with the heterocyclic thioamides, thiourea (TU), 2-mercapto-1-methylimidazole (MMI), 2-mercapto-benzimidazole (MBZIM), 2-mercapto-5-methyl-benzimidazole (MMBZIM), 5-ethoxy-2-mercapto-benzimidazole (EtMBZIM), 2-mercapto-3,4,5,6-tetrahydro-pyrimidine (tHPMT), 2-mercaptopyridine (PYT), 2-mercapto-thiazolidine (MTZD), 3-methyl-2-mercaptobenzothiazole (MMBZT), and 2-mercaptopyrimidine (PMTH) of formulas [SbBr(3)(TU)(2)] (1), [SbBr(3)(MMI)(2)] (2), {[SbBr(2)(MBZIM)(4)](+) [Br](-) H(2)O} (3), {[SbBr(2)(mu(2)-Br)(MMBZIM)(2)](2)} (4), {[SbBr(2)(mu(2)-Br)(EtMBZIM)(2)](2) MeOH} (5), {[SbBr(3)(mu(2)-S-tHPMT)(tHPMT)](n)} (6), {[SbBr(2)(mu(2)-Br)(PYT)(2))(n)} (7), {[SbBr(2)(mu(2)-Br)(MTZD)(2)](n)} (8), [SbBr(3)(MMBZT)(2)] (9), and {[SbBr(5)](2-)[(PMTH(2)(+))(2)]} (10) have been synthesized and characterized by elemental analysis, conductivity measurements, FTIR spectroscopy, FT-Raman spectroscopy, TG-DTA analysis, and X-ray powder diffraction. The crystal structures of 3, 4, 5, 6, 7, 8, and 10 were also determined by X-ray diffraction. In 3, four sulfur atoms from thione ligands and two bromide ions form an octahedral (O(h)) cationic [SbS(4)Br(2)](+) species in which the two bromide anions lie at axial positions. A third bromide counteranion neutralizes the whole complex. 4 and 5 are dimers, whereas 6, 7 and 8 are polymers, built up by monomeric units of square pyramidal (SP) geometry around the metal center, which were formed by two sulfur atoms of thioamide ligands and three bromide ions. Finally, 10 is ionic salt containing 1D polymeric network of {[SbBr(5)](2-)}(n) anions and (-)[(PMTH(2)(+))2] counter cations in the lattice. The complexes showed mostly a moderate cytostatic activity against a variety of tumor cell lines.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1021/ic8019205-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19235983-
heal.identifier.secondaryhttp://pubs.acs.org/doi/pdfplus/10.1021/ic8019205-
heal.journalNameInorg Chemen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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