Comparison of the therapeutic effects of two vanadium complexes administered at low doses on benzo[a]pyrene-induced malignant tumors in rats
| dc.contributor.author | Evangelou, A. | en |
| dc.contributor.author | Karkabounas, S. | en |
| dc.contributor.author | Kalpouzos, G. | en |
| dc.contributor.author | Malamas, M. | en |
| dc.contributor.author | Liasko, R. | en |
| dc.contributor.author | Stefanou, D. | en |
| dc.contributor.author | Vlahos, A. T. | en |
| dc.contributor.author | Kabanos, T. A. | en |
| dc.date.accessioned | 2015-11-24T16:54:11Z | |
| dc.date.available | 2015-11-24T16:54:11Z | |
| dc.identifier.issn | 0304-3835 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/10125 | |
| dc.rights | Default Licence | - |
| dc.subject | benzo[a]pyrene | en |
| dc.subject | leiomyosarcomas | en |
| dc.subject | vanadium(iii) complexes | en |
| dc.subject | l-cysteine | en |
| dc.subject | n-(2-mercaptopropionyl)-glycine | en |
| dc.subject | wistar rats | en |
| dc.subject | DNA-synthesis | en |
| dc.subject | diethylnitrosamine | en |
| dc.subject | vanadate | en |
| dc.subject | growth | en |
| dc.title | Comparison of the therapeutic effects of two vanadium complexes administered at low doses on benzo[a]pyrene-induced malignant tumors in rats | en |
| heal.abstract | The antitumor effects of low dose administration of the vanadium(III) complexes with L-cysteine (complex 1) and N-(2-mercaptopropionyl)-glycine (complex 2) were compared on benzo[a]pyrene (BaP)-induced tumors in Wistar rats. Male Wistar rats, injected with 10.0 mg of BaP, were divided into one Control (C-G) and two treatment (TR-G) groups of 17 animals each, Animals of the first treatment group were administered complex 2 (TR-2 group) and those of the second group were administered complex 1 (TR-1 group) at doses of 100 mu g of vanadium per os daily, starting from the day a palpable tumor was developed till their death, BaP injection induced a 100% tumor (leiomyosarcomas) development in the animals of all groups. Administration of complex 1 to the animals resulted in a significant prolongation of the mean survival time, a complete remission of 17.6% of the tumors developed, a significant reduction of the carcinogenic potency (CP) of BaP and of the tumor growth rate (TGR) in TR-1 group animals, compared to the control and the TR-2 group, In marked contrast, complex 2 failed at the doses administered to exert any significant modulation of the above mentioned parameters. Results indicate that at low (100 mu g/day) concentrations of vanadium, complex 1 exerts a significant anticarcinogenic effect on experimentally-induced leiomyosarcomas in rats, whereas complex 2 has no effect when administered at the same low concentrations of vanadium. (C) 1997 Elsevier Science Ireland Ltd. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://A1997YD69700014 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0304383597002784/1-s2.0-S0304383597002784-main.pdf?_tid=57630ce2d89a342d9468845250573796&acdnat=1333030400_bd0514ec6ce53e83f1ce9b6ee502b1e8 | - |
| heal.journalName | Cancer Lett | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1997 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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