Multinuclear (C-13, O-17, Fe-57) NMR studies of carbonmonoxy heme proteins and synthetic model compounds
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kalodimos, C. G.
Gerothanassis, I. P.
Pierattelli, R.
Troganis, A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Elsevier
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Inorg Biochem
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
C-13, O-17 and Fe-57 NMR spectra of several carbonmonoxy hemoprotein models with varying polar and steric effects of the distal organic superstructure, constraints of the proximal side, and porphyrin ruffling are reported. Both heme models and heme proteins obey a similar excellent linear delta(C-13) versus nu(C-O) relationship which is primarily due to modulation of pi-back-bonding from the Fe d(pi) to CO pi* orbital by the distal pocket polar interactions. The lack of correlation between delta(C-13) and delta(O-17) suggests that the two probes do not reflect a similar type of electronic and structural perturbation. delta(O-17) is not primarily influenced by the local distal field interactions and does not correlate with any single structural property of the Fe-C-O unit; however, atropisomerism and deformation of the porphyrin geometry appear to play a significant role. Fe-57 shieldings Vary by nearly 900 ppm among various hemes and an excellent correlation was found between delta(Fe-57) and the absolute crystallographic average displacement of the meso carbon atoms, \C-m\ relative to the porphyrin core mean plane. The excellent correlation between iron-57 shieldings and the average shieldings of the meso carbons of the porphyrin skeleton of TPP derivatives suggests that the two probes reflect a similar type of electronic and structural perturbation which is primarily porphyrin ruffling. (C) 2000 Elsevier Science Inc. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
hemoproteins, synthetic model compounds, multinuclear magnetic resonance spectroscopy, nuclear-magnetic-resonance, c-o unit, superstructured hemoprotein models, ray structural data, vibrational frequencies, chemical-shifts, monoxide binding, raman-spectroscopy, porphyrin, iron(ii)
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000086988500054
http://ac.els-cdn.com/S0162013499002391/1-s2.0-S0162013499002391-main.pdf?_tid=2ca9719ec7041a90fae4c907ee8b128c&acdnat=1333029795_ab7762d53f18f9c93a1c882558e05f2a
http://ac.els-cdn.com/S0162013499002391/1-s2.0-S0162013499002391-main.pdf?_tid=2ca9719ec7041a90fae4c907ee8b128c&acdnat=1333029795_ab7762d53f18f9c93a1c882558e05f2a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας