Carcinogenic properties of pharmaceutical agents evaluated in the IARC Monographs programme
| dc.contributor.author | Marselos, M. | en |
| dc.contributor.author | Vainio, H. | en |
| dc.date.accessioned | 2015-11-24T19:31:38Z | |
| dc.date.available | 2015-11-24T19:31:38Z | |
| dc.identifier.issn | 0143-3334 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23297 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Carcinogens/*toxicity | en |
| dc.subject | Humans | en |
| dc.subject | Pharmaceutical Preparations/*adverse effects | en |
| dc.title | Carcinogenic properties of pharmaceutical agents evaluated in the IARC Monographs programme | en |
| heal.abstract | Almost 200 pharmaceutical chemicals and groups of drugs have been evaluated for their carcinogenic properties by working groups convened by the International Agency for the Research on Cancer. Therapeutic agents are exceptional environmental carcinogens in that humans are exposed to relatively pure substances at well-defined dosages. Of those evaluated, 20 are conclusively carcinogenic to humans and 52 are probably or possibly carcinogenic. The human tissues most often affected are bone marrow, skin, urinary bladder, liver, lymphatic tissue and endometrium. In cases in which there is sufficient evidence for carcinogenicity from both epidemiological and experimental studies, the similarity between humans and animals with regard to the target organs involved is close (85%). Since data on carcinogenicity exist for several groups of pharmaceuticals, risk versus benefit evaluations should be made carefully in relation to possible clinical applications. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/1934255 | - |
| heal.identifier.secondary | http://carcin.oxfordjournals.org/content/12/10/1751.full.pdf | - |
| heal.journalName | Carcinogenesis | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1991 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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