Modified natural cycle for IVF does not offer a realistic chance of parenthood in poor responders with high day 3 FSH levels, as a last resort prior to oocyte donation

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dc.contributor.authorKolibianakis, E.en
dc.contributor.authorZikopoulos, K.en
dc.contributor.authorCamus, M.en
dc.contributor.authorTournaye, H.en
dc.contributor.authorVan Steirteghem, A.en
dc.contributor.authorDevroey, P.en
dc.date.accessioned2015-11-24T19:04:10Z
dc.date.available2015-11-24T19:04:10Z
dc.identifier.issn0268-1161-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19988
dc.rightsDefault Licence-
dc.subjectChorionic Gonadotropin/therapeutic useen
dc.subjectEmbryo Transferen
dc.subjectFemaleen
dc.subjectFertilization in Vitro/*methodsen
dc.subjectFollicle Stimulating Hormone/*blood/pharmacologyen
dc.subjectFollicular Phase/drug effects/physiologyen
dc.subjectGonadotropin-Releasing Hormone/antagonists & inhibitorsen
dc.subjectHumansen
dc.subjectInfertility, Female/drug therapy/*therapyen
dc.subjectOocyte Donationen
dc.subjectOocytes/drug effects/*physiologyen
dc.subjectOvarian Follicle/drug effects/physiology/ultrasonographyen
dc.subjectOvulation Induction/*methodsen
dc.subjectPregnancyen
dc.subjectTreatment Failureen
dc.titleModified natural cycle for IVF does not offer a realistic chance of parenthood in poor responders with high day 3 FSH levels, as a last resort prior to oocyte donationen
heal.abstractBACKGROUND: The purpose of this study was to evaluate the use of the modified natural cycle (MNC) for IVF in poor responders as a last resort prior to oocyte donation. METHODS: Thirty-two patients with a regular menstrual cycle, FSH levels on day 3 of the cycle >12 IU/l and one or more failed IVF cycles with five or fewer cumulus-oocyte complexes (COCs) retrieved were included in this prospective study. Recombinant FSH 100 IU and GnRH antagonist 0.25 mg/day were started concomitantly when a follicle with a mean diameter of 14 mm was present at ultrasound. HCG 10 000 IU was administered as soon as the mean follicular diameter was > or =16 mm. RESULTS: Twenty-five out of 78 cycles performed (32.1%) did not result in oocyte retrieval. In nine out of 53 cycles (16.9%) in which oocyte retrieval was performed, no COCs were retrieved. Following fertilization, embryo transfer was performed in 19 out of 44 cycles in which COCs were retrieved (43.2%). No ongoing pregnancy was achieved in 78 MNCs (0.0%; 95% confidence interval 0.0-4.7). CONCLUSIONS: MNC does not offer a realistic chance of parenthood in patients with high levels of FSH on day 3 of the cycle and previous poor response to ovarian stimulation, when offered as a last resort prior to oocyte donation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1093/humrep/deh452-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15471941-
heal.identifier.secondaryhttp://humrep.oxfordjournals.org/content/19/11/2545.full.pdf-
heal.journalNameHum Reproden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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