Predictive value of c-erbB-2 and cathepsin-D for Greek breast cancer patients using univariate and multivariate analysis
| dc.contributor.author | Scorilas, A. | en |
| dc.contributor.author | Yotis, J. | en |
| dc.contributor.author | Pateras, C. | en |
| dc.contributor.author | Trangas, T. | en |
| dc.contributor.author | Talieri, M. | en |
| dc.date.accessioned | 2015-11-24T16:32:15Z | |
| dc.date.available | 2015-11-24T16:32:15Z | |
| dc.identifier.issn | 1078-0432 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7533 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Aged, 80 and over | en |
| dc.subject | Breast Neoplasms/diagnosis/enzymology/*metabolism/mortality | en |
| dc.subject | Cathepsin D/*metabolism | en |
| dc.subject | Disease-Free Survival | en |
| dc.subject | Female | en |
| dc.subject | Gene Amplification | en |
| dc.subject | Greece | en |
| dc.subject | Humans | en |
| dc.subject | Logistic Models | en |
| dc.subject | Lymphatic Metastasis/diagnosis | en |
| dc.subject | Middle Aged | en |
| dc.subject | Multiv | en |
| dc.title | Predictive value of c-erbB-2 and cathepsin-D for Greek breast cancer patients using univariate and multivariate analysis | en |
| heal.abstract | The value of various prognostic factors in breast cancer patients has been determined in a number of studies. One hundred thirty-eight Greek women were followed up over a 5-year period after surgery for breast cancer. Amplification and overexpression of c-erbB-2 was found in 22.4% and 29.7% of the respective cases, and the concentration of total cytosolic Cathepsin-D (CD) in 46.4% of them was high (> or = 60 pmol/mg protein). The examined biological variables were compared with standard clinicopathological prognostic factors for the disease and related to early relapse (ER; before 3 years), relapse-free survival (RFS; median, 5 years), and overall survival (OS; median, 5 years). It was found that high CD levels significantly shorten ER of both node-negative and node-positive patients (P < 0.0001 and P = 0.002, respectively) and have prognostic value for RFS and OS of node-negative patients (P = 0.0012 and P = 0.0288, respectively), but lose their value as relapse predictors for node-positive patients for periods longer than 3 years. Overexpression of c-erbB-2 was found to be predictive for OS of node-positive and -negative patients (P = 0.0048 and P = 0.0285, respectively), but its predictive power was weak for ER (P = 0.0456) and RFS (P = 0.0455) of node-negative patients and disappeared for node-positive patients. c-erbB-2 amplification offers minimal assistance to the prediction. In conclusion, high CD concentration is indicative of ER of patients, and c-erbB-2 overexpression correlates with OS of patients. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10213217 | - |
| heal.identifier.secondary | http://clincancerres.aacrjournals.org/content/5/4/815.full.pdf | - |
| heal.journalName | Clin Cancer Res | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1999 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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