Behavioral effects of amphetamine and apomorphine after striatal lesions in the rat
Φόρτωση...
Ημερομηνία
Συγγραφείς
Antoniou, K.
Kafetzopoulos, E.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Pharmacol Biochem Behav
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
It is well established that denervation of the dorsal striatum by its dopaminergic afferents attenuates the stereotyped response to d-amphetamine, which can be considered as an extreme form of motor activation. However, it is difficult to sustain the view that this structure serves primary motor control function because the role of dopamine in the striatum remains difficult to understand. In this study, we compared the effects of two dopaminergic agonists, d-amphetamine and apomorphine, after dorsal striatal lesions with ibotenic acid using a computerized scoring of the behavior. Although d-amphetamine- and apomorphine-induced locomotor activity was no different between lesioned and nonlesioned rats in photobeam activity cages, the structure of their behavioral pattern was quite different. Freezing, a usual response after d-amphetamine, was blocked by the lesion. Lesioned rats exhibited less standing than nonlesioned after d-amphetamine, apomorphine, or saline treatment. Moving was increased in lesioned rats after a low dose of d-amphetamine (0.5 mg/kg) or apomorphine (0.5 mg/kg), while d-amphetamine induced in the same rats an increase of rearing. Stereotyped behavior after both drugs at high doses was not affected by striatal lesion. These results indicate that the dorsal striatum is not involved only in the control of stereotypy, as has been suggested using 6-hydroxydopamine lesions, but also plays a major role in the mediation of behavioral activation in response to stimulant drugs.
Περιγραφή
Λέξεις-κλειδιά
Animals, Apomorphine/*pharmacology, Behavior, Animal/*drug effects, Corpus Striatum/*physiology, Dextroamphetamine/*pharmacology, Grooming/drug effects, Ibotenic Acid/pharmacology, Male, Motor Activity/drug effects, Rats, Rats, Wistar, Stereotyped Behavior/drug effects, Yawning/drug effects
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/1448467
http://ac.els-cdn.com/009130579290399Z/1-s2.0-009130579290399Z-main.pdf?_tid=bc10a34c064b1bd94f19dcaf2fb618d0&acdnat=1332923821_e565bb5f217827cdde945c8d057bae44
http://ac.els-cdn.com/009130579290399Z/1-s2.0-009130579290399Z-main.pdf?_tid=bc10a34c064b1bd94f19dcaf2fb618d0&acdnat=1332923821_e565bb5f217827cdde945c8d057bae44
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής