FGFR-2 and -3 play an important role in initial stages of oral oncogenesis

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dc.contributor.authorVairaktaris, E.en
dc.contributor.authorRagos, V.en
dc.contributor.authorYapijakis, C.en
dc.contributor.authorDerka, S.en
dc.contributor.authorVassiliou, S.en
dc.contributor.authorNkenke, E.en
dc.contributor.authorYannopoulos, A.en
dc.contributor.authorSpyridonidou, S.en
dc.contributor.authorVylliotis, A.en
dc.contributor.authorPapakosta, V.en
dc.contributor.authorLoukeri, S.en
dc.contributor.authorLazaris, A.en
dc.contributor.authorTesseromatis, C.en
dc.contributor.authorTsigris, C.en
dc.contributor.authorPatsouris, E.en
dc.date.accessioned2015-11-24T19:15:52Z
dc.date.available2015-11-24T19:15:52Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21577
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectCarcinoma, Squamous Cell/*physiopathologyen
dc.subjectCricetinaeen
dc.subjectImmunohistochemistryen
dc.subjectMaleen
dc.subjectMesocricetusen
dc.subjectMouth Neoplasms/*physiopathologyen
dc.subjectReceptor, Fibroblast Growth Factor, Type 2/*physiologyen
dc.subjectReceptor, Fibroblast Growth Factor, Type 3/*physiologyen
dc.titleFGFR-2 and -3 play an important role in initial stages of oral oncogenesisen
heal.abstractBACKGROUND: FGFR-2 and FGFR-3 (fibroblast growth factor receptors) have been shown to play an important role in several processes including carcinogenesis. This study was designed to determine gradual FGFR-2 and FGFR-3 expression in sequential stages of oral carcinogenesis in an experimental animal system of Syrian golden hamsters. MATERIALS AND METHODS: Tissue sections ranging from normal mucosa to squamous cell carcinoma were studied using monoclonal antibodies against FGFR-2 and FGFR-3 proteins. RESULTS: A significant elevation was revealed in both FGFR-2 and FGFR-3 expression during the stages of dysplasia and early invasion, while in the later stages of oral carcinogenesis the expression of both FGFR-2 and FGFR-3 decreased although not significantly. CONCLUSION: Our findings indicate that FGFR-2 and FGFR-3 seem to play an important role in the initial stages of oral cancer progression.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17201136-
heal.journalNameAnticancer Researchen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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