2-amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid as an N-terminal surrogate in amino acid and peptide analogues

Bissyris, E.; Belekos, D.; Magafa, V.; Tsoungas, P. G.; Varvounis, G.; Cordopatis, P.

2-amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid as an N-terminal surrogate in amino acid and peptide analogues

dc.contributor.author	Bissyris, E.	en
dc.contributor.author	Belekos, D.	en
dc.contributor.author	Magafa, V.	en
dc.contributor.author	Tsoungas, P. G.	en
dc.contributor.author	Varvounis, G.	en
dc.contributor.author	Cordopatis, P.	en
dc.date.accessioned	2015-11-24T16:39:51Z
dc.date.available	2015-11-24T16:39:51Z
dc.identifier.issn	0039-7881	-
dc.identifier.uri	https://olympias.lib.uoi.gr/jspui/handle/123456789/8199
dc.rights	Default Licence	-
dc.subject	heterocycles	en
dc.subject	amino acids	en
dc.subject	peptides	en
dc.subject	thienopyrimidine	en
dc.subject	angiotensin ii	en
dc.subject	solid-phase synthesis	en
dc.subject	angiotensin-ii	en
dc.subject	position 5	en
dc.subject	thienopyrimidine	en
dc.subject	derivatives	en
dc.subject	receptor	en
dc.subject	thieno<2,3-d>pyrimidines	en
dc.subject	antagonist	en
dc.subject	potent	en
dc.title	2-amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid as an N-terminal surrogate in amino acid and peptide analogues	en
heal.abstract	2-Amino-4-pyrrolidinothieno[2,3-d]pyrimidine-6-carboxylic acid (4) (ATPC) is an unnatural amino acid with promise in applications as a building block for the synthesis of peptidomimetics. ATPC was obtained from both 3a and 3b thienopyrimidines by hydrolysis and hydrogenolysis, respectively. The synthesis of eleven ATPC-amino acids and two ATPC-peptides is described. ATPC is incorporated as N-terminal moiety in solution or solid-phase peptide synthesis using Boc or Fmoc methodology and without protection of the ATPC amino group.	en
heal.access	campus	-
heal.fullTextAvailability	TRUE	-
heal.identifier.primary	DOI 10.1055/s-2005-918426	-
heal.identifier.secondary	<Go to ISI>://000233495500022	-
heal.identifier.secondary	https://www.thieme-connect.de/ejournals/pdf/10.1055/s-2005-918426.pdf	-
heal.journalName	Synthesis-Stuttgart	en
heal.journalType	peer reviewed	-
heal.language	en	-
heal.publicationDate	2005	-
heal.publisher	Thieme Publishing	en
heal.recordProvider	Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας	el
heal.type	journalArticle	-
heal.type.el	Άρθρο Περιοδικού	el
heal.type.en	Journal article	en

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