Intrapericardial drug delivery: pharmacologic properties and long-term safety in swine
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kolettis, T. M.
Kazakos, N.
Katsouras, C. S.
Niokou, D.
Pappa, L.
Koulouras, V.
Stefanou, P.
Seferiadis, C.
Malamou-Mitsi, V.
Michalis, L. K.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Int J Cardiol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Intrapericardial drug delivery is a promising new technique, but the pharmacologic properties of various agents delivered via this route are not known. Furthermore, the long-term safety of intrapericardial catheters has not been previously examined. METHODS: Using a pericardial access device, a catheter connected to a drug-delivery system was implanted in five pigs. Plasma levels and electrocardiographic measurements were obtained after intravenous and intrapericardial administration of digoxin and procainamide. Histological examination was performed after the device had been implanted for a total of 6 months. RESULTS: The QTc interval did not change significantly after digoxin or procainamide intravenous administration. QTc decreased by 47+/-23 ms (p=0.046) 8 h after digoxin intrapericardial administration and increased by 128+/-60 ms (p=0.002) 1 h after procainamide intrapericardial administration. The QRS duration did not change significantly after intravenous administration of either agent, but it increased by 17+/-9 ms (p=0.004) 1 h and by 15+/-4 ms (p=0.01) 8 h after procainamide intrapericardial administration. After intravenous procainamide the RR interval decreased, but it did not change significantly after intrapericardial administration of either agent. Histology showed moderate inflammatory infiltration and fibrosis adjacent to the catheter. CONCLUSIONS: Intrapericardial delivery of digitalis and procainamide produces unique electrophysiological properties. In contrast to satisfactory success of the implantation technique, long-term dwell of the catheter in the pericardium induces moderate, albeit probably clinically significant, fibrosis.
Περιγραφή
Λέξεις-κλειδιά
Animals, Anti-Arrhythmia Agents/*administration & dosage, Catheters, Indwelling, Digitalis Glycosides/*administration & dosage, Heart Conduction System/drug effects, Male, Procainamide/*administration & dosage, Swine
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/15771922
http://ac.els-cdn.com/S0167527304002839/1-s2.0-S0167527304002839-main.pdf?_tid=3076fcbd91cc2c68a37c43e1f806d9a8&acdnat=1337844819_a5359af270e8da78ab9ed91c0fff66fb
http://ac.els-cdn.com/S0167527304002839/1-s2.0-S0167527304002839-main.pdf?_tid=3076fcbd91cc2c68a37c43e1f806d9a8&acdnat=1337844819_a5359af270e8da78ab9ed91c0fff66fb
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής